Two cases of extramedullary acute promyelocytic leukemia
Two cases of extramedullary acute promyelocytic leukemia
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髓外急性早幼粒细胞白血病二例
DOI：
10.1002/1097-0142(19950701)76:1
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发表时间：
1995
期刊：
影响因子：
6.2
通讯作者：
R. Warrell
中科院分区：
文献类型：
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作者：
M. Benekli;M. C. Savaş;Í. Haznedaroglu;S. Dündar;M. Weiss;R. Warrell
我怀着极大的兴趣阅读了山崎等人最近的文章。肺腺癌切除后新血管形成与复发和血行转移的相关性。尽管作者讨论了新形成的血管和原始血管的形状和免疫染色的差异，但他们在没有进一步推理的情况下得出结论，所有被计数的血管都是最近起源的，因此是由肿瘤组织诱导的。考虑到肺的独特解剖结构，包括由细血管间隔隔开的充满空气的蜂窝状空间，他们研究中计数的血管的性质值得进一步分析。与在实体组织(如乳腺癌、前列腺癌)中扩散的癌症不同，肺腺癌是通过填充“空的”肺泡空间而不破坏肺壁和毛细血管而生长的，2肺腺癌用来提供营养支持。这些肿瘤的很大一部分是由肺泡内非侵袭性生长组成的。在周围区域发现的毛细血管是血管计数的主要焦点，应该被认为是原始的肺毛细血管，直到证明并非如此。
I have read with great interest the recent article by Yamazaki et al.’ correlating the formation of new vessels with relapse and hematogenous metastases after the resection of pulmonary adenocarcinomas. Although the authors discussed differences of shape and immunostaining of the newly formed and original vessels, they concluded without further reasoning that all of the vessels counted were of recent origin and hence induced by tumor tissue. Considering the unique anatomic structure of the lung consisting of a honeycomb of air-filled spaces separated by thin vascularized septa, the nature of counted vessels in their study deserves further analysis. Unlike carcinomas spreading in solid tissues (e.g., breast, prostate), lung adenocarcinomas grow by filling the ”empty” alveolar spaces without destroying their walls and their capillaries,2 which they use for nutritional support. Substantial parts of these tumors consist of such intraalveolar noninvasive growth. Capillaries found in the peripheral regions that were the primary focus of the vessel counting should be considered the original pulmonary capillaries until proven otherwise.