Differential effects of dopaminergic agents on locomotor sensitisation and on the reinstatement of cocaine-seeking and food-seeking behaviour
Differential effects of dopaminergic agents on locomotor sensitisation and on the reinstatement of cocaine-seeking and food-seeking behaviour
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DOI：
10.1007/s00213-004-1839-1
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发表时间：
2004-10-01
影响因子：
3.4
通讯作者：
Cador, M
中科院分区：
文献类型：
--
作者：
Dias, C;Lachize, S;Cador, M
Rationale: The dopaminergic pathways are involved in natural and drug reward related processes. Objectives: To compare the respective involvement of the dopaminergic receptors D-1, D-2 and D-3 in natural-seeking versus drug-seeking behaviour and evaluate any concomitant expression of locomotor sensitisation. Methods: In separate experiments, male Wistar rats were trained to self-administer cocaine (0.25 mg/infusion) or to press a lever to obtain food pellets. Following a prolonged period of extinction, reinstatement of lever responding was measured following non-contingent food delivery, cocaine (15 mg/kg), D-1-like (SKF 82958, 0.25 mg/kg), D-2-like (quinelorane, 0.25 mg/kg) and D-3-like (7-OHDPAT, 0.25 mg/kg) agonists. To demonstrate parallel expression of behavioural sensitisation, locomotor activity was recorded during the reinstatement sessions. Results: Cocaine and quinelorane administrations reinstated cocaine-seeking behaviour and induced the expression of locomotor sensitisation, whereas SKF 82958 and 7-OHDPAT had either no effect or non-specific effects. In the food-seeking experiment, we found that quinelorane and 7-OHDPAT did not reinstate lever pressing. Cocaine increased responding on both active and inactive levers, whereas SKF 82958 had a more specific effect with higher responding on the previously food-associated lever. Conclusions: Our results indicate that expression of locomotor sensitisation and reinstatement of cocaine-seeking but not food-seeking behaviours are in part supported by common dopaminergic substrates, among which the D-2 receptors play a crucial role.
