SSeCKS is a Suppressor in Schwann Cell Differentiation and Myelination
SSeCKS is a Suppressor in Schwann Cell Differentiation and Myelination
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SSeCKS 是雪旺细胞分化和髓鞘形成的抑制剂
DOI：
10.1007/s11064-009-0045-2
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发表时间：
2010-02-01
影响因子：
4.4
通讯作者：
Shen, Aiguo
中科院分区：
文献类型：
--
作者：
Ji, Yuhong;Tao, Tao;Shen, Aiguo
Src抑制的蛋白激酶C底物（SSeCKS）在分化过程中起重要作用。在坐骨神经损伤后再生过程中，SSeCKS表达减少，主要在雪旺细胞中。然而，SSeCKS在雪旺细胞分化中的功能尚不清楚。我们观察到SSeCKS在分化的雪旺细胞中减少。在长期SSeCKS减少的雪旺细胞中，细胞形态发生变化，cAMP诱导的髓鞘基因表达加速。在SSeCKS抑制的雪旺细胞与背根神经节（DRG）共培养中，髓鞘形成也增强。此外，我们发现SSeCKS表达的抑制促进cAMP处理的Schwann细胞中Akt丝氨酸473磷酸化。总之，我们的数据表明，SSeCKS是一个负调控髓鞘神经胶质细胞分化。
Src-suppressed protein kinase C substrate (SSeCKS) plays an important role in the differentiation process. In regeneration of sciatic nerve injury, expression of SSeCKS decreases, mainly in Schwann cells. However, the function of SSeCKS in Schwann cells differentiation remains unclear. We observed that SSeCKS was decreased in differentiated Schwann cells. In long-term SSeCKS-reduced Schwann cells, cell morphology changed and myelin gene expression induced by cAMP was accelerated. Myelination was also enhanced in SSeCKS-suppressed Schwann cells co-culture with dorsal root ganglion (DRG). In addition, we found suppression of SSeCKS expression promoted Akt serine 473 phosphorylation in cAMP-treated Schwann cells. In summary, our data indicated that SSeCKS was a negative regulator of myelinating glia differentiation.