Protein function from the perspective of molecular interactions and genetic networks.
Protein function from the perspective of molecular interactions and genetic networks.
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DOI：
10.1093/bib/2.1.38
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发表时间：
2001-03-01
影响因子：
9.5
通讯作者：
Jacq, B
中科院分区：
文献类型：
--
作者：
Jacq, B
蛋白质功能是一个复杂的概念，现在从生物信息学和基因组学的角度重新受到关注。在对用于破译基因/蛋白质功能的实验方法的原理进行一般性讨论后，讨论了新的高通量方法在功能发现方面所做出的贡献。最近的工作功能本体和必要性描述功能的复杂性层次的背景下。分子相互作用和遗传网络的概念进行了讨论，导致一个有用的新框架，使用新的工具，如二维相互作用图来描述蛋白质的功能。最后，提出了相互作用数据可以用来开发新的方法，蛋白质的功能分类。酵母染色体蛋白质的真实的数据集上的功能比较的一个例子。
Protein function is a complex notion, which is now receiving renewed attention from a bioinformatics and genomics perspective. After a general discussion of the principles of experimental methods employed to decipher gene/protein function, the contributions made by new, high-throughput methods in terms of function discovery are discussed. Recent work on functional ontologies and the necessity to describe function within the context of hierarchical levels of complexity are presented. The concepts of molecular interactions and genetic networks are then discussed, leading to a useful new framework with which to describe protein function using new tools such as 2D interaction maps. Finally, it is proposed that interaction data could be used to develop new methods for the functional classification of proteins. An example of functional comparisons on a real data set of yeast chromosomal proteins is presented.