Estrogen and mechanisms of vascular protection.
Estrogen and mechanisms of vascular protection.
复制标题
DOI：
10.1161/atvbaha.108.182279
复制
发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Oparil S
中科院分区：
文献类型：
--
作者：
Xing D;Nozell S;Chen YF;Hage F;Oparil S
雌激素具有抗炎和血管保护作用，当给予年轻女性或实验动物时，似乎在老年受试者中转化为促炎和血管毒性作用，特别是那些长期无激素的人。临床研究提出了许多关于雌激素对血管影响的重要问题，这些问题在人类受试者中不易回答。本文综述了雌激素调节动脉和离体血管平滑肌细胞损伤诱导的炎症、生长因子表达和氧化应激的细胞/分子机制，重点介绍了雌激素受体和核因子-κB（NFκB）信号通路的作用，以及这些保护机制在老年受试者中丢失的证据。
Estrogen has anti-inflammatory and vasoprotective effects when administered to young women or experimental animals that appear to be converted to pro-inflammatory and vasotoxic effects in older subjects, particularly those that have been hormone free for long periods. Clinical studies have raised many important questions about the vascular effects of estrogen that cannot easily be answered in human subjects. Here we review cellular/molecular mechanisms by which estrogen modulates injury-induced inflammation, growth factor expression and oxidative stress in arteries and isolated vascular smooth muscle cells, with emphasis on the role of estrogen receptors and the Nuclear Factor-κB (NFκB) signaling pathway, as well as evidence that these protective mechanisms are lost in aging subjects.