Brain plasticity for verbal and visual memories in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: An fMRI study
Brain plasticity for verbal and visual memories in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: An fMRI study
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DOI：
10.1002/hbm.21432
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发表时间：
2013-01-01
影响因子：
4.8
通讯作者：
Cendes, Fernando
中科院分区：
文献类型：
--
作者：
Alessio, Andrea;Pereira, Fabricio R. S.;Cendes, Fernando
本研究旨在通过功能性磁共振成像（fMRI）技术，对正常对照组和单侧内侧颞叶癫痫（MTLE）合并单侧海马硬化（HS）患者的言语和视觉记忆加工相关脑区进行研究。样本包括9名正常对照，8名右MTLE患者和9名左MTLE患者。所有受试者都接受了言语和视觉记忆范式的功能磁共振成像，包括编码和立即回忆17个抽象单词和17幅抽象图画。一个复杂的网络，包括顶叶，颞叶和额叶皮质似乎参与了言语记忆的编码和提取正常对照。虽然在两个患者组中发现了相似的激活区域，但左侧HS组中此类激活的范围更大。左侧HS患者也倾向于表现出更多的双侧或右侧编码相关激活。这一发现表明，由于左侧MTL系统的故障，这些患者的文字记忆加工区域的功能重组。至于视觉记忆的编码和提取，我们的研究结果支持这一认知功能在大脑中的更广泛和双边的代表性的假设。与正常对照组相比，左侧HS组的编码招募了更广泛的皮质区，这在右侧HS组中甚至更广泛，可能是为了补偿他们的右侧内侧颞叶功能障碍。相比之下，右HS组表现出更少的激活区域，在立即回忆比其他两组，可能与他们更大的困难，在处理视觉记忆内容。^Brain Mapp，2013. (c)2011 Wiley Periodicals，Inc.
We aimed to identify the brain areas involved in verbal and visual memory processing in normal controls and patients with unilateral mesial temporal lobe epilepsy (MTLE) associated with unilateral hippocampal sclerosis (HS) by means of functional magnetic resonance imaging (fMRI). The sample comprised nine normal controls, eight patients with right MTLE, and nine patients with left MTLE. All subjects underwent fMRI with verbal and visual memory paradigms, consisting of encoding and immediate recall of 17 abstract words and 17 abstract drawings. A complex network including parietal, temporal, and frontal cortices seems to be involved in verbal memory encoding and retrieval in normal controls. Although similar areas of activation were identified in both patient groups, the extension of such activations was larger in the left-HS group. Patients with left HS also tended to exhibit more bilateral or right lateralized encoding related activations. This finding suggests a functional reorganization of verbal memory processing areas in these patients due to the failure of left MTL system. As regards visual memory encoding and retrieval, our findings support the hypothesis of a more diffuse and bilateral representation of this cognitive function in the brain. Compared to normal controls, encoding in the left-HS group recruited more widespread cortical areas, which were even more widespread in the right-HS group probably to compensate for their right mesial temporal dysfunction. In contrast, the right-HS group exhibited fewer activated areas during immediate recall than the other two groups, probably related to their greater difficulty in dealing with visual memory content. Hum Brain Mapp, 2013. (c) 2011 Wiley Periodicals, Inc.