Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
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DOI：
10.1038/nn2038
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发表时间：
2008-02-01
影响因子：
25
通讯作者：
Barde, Yves-Alain
中科院分区：
文献类型：
--
作者：
Matsumoto, Tomoya;Rauskolb, Stefanie;Barde, Yves-Alain
前和成熟的BDNF激活非常不同的受体和细胞内途径，可能导致神经元死亡或存活。在这里，我们研究了内源性BDNF在小鼠神经元中使用敏感的试剂的生物化学，并发现，前BDNF细胞内迅速转化为成熟的BDNF，后者被存储和释放的兴奋性输入。
Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.