Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones
Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones
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DOI：
10.1002/bdd.771
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发表时间：
2011-11-01
影响因子：
2.1
通讯作者：
Zuo, Zhong
中科院分区：
文献类型：
--
作者：
Li, Chenrui;Lin, Ge;Zuo, Zhong
黄芩为药用植物黄芩的干燥根。它具有多种治疗作用，在传统配方和现代草药中有着悠久的应用历史。已证实类黄酮是最丰富的成分并能产生这些治疗效果。黄芩中的六种黄酮类化合物已被证明是主要的生物活性黄酮，以苷元（黄芩素、汉黄芩素、木木精A）和苷类（黄芩苷、汉黄芩苷、木木精A-7-葡萄糖醛酸苷）的形式存在。所有六种黄酮都具有药理活性，在治疗炎症、癌症和病毒相关疾病方面显示出巨大潜力。目前的综述涵盖了草药黄芩的制备、其主要生物活性成分的定量以及拟议的六种生物活性黄酮的药理作用。此外，本综述总结了迄今为止报道的生物活性黄酮的药代动力学特征，可用于进一步改进其药代动力学研究。此外，由于黄芩中存在丰富的共存生物活性成分，我们的综述进一步记录了它们之间的药代动力学相互作用。版权所有 (C) 2011 John Wiley & Sons, Ltd.
Radix Scutellariae is the dried root of the medicinal plant Scutellariae baicalensis Georgi. It exhibits a variety of therapeutic effects and has a long history of application in traditional formulations as well as in modern herbal medications. It has been confirmed that flavonoids are the most abundant constituents and induce these therapeutic effects. Six flavones are proven to be the major bioactive flavones in Radix Scutellariae existing in the forms of aglycones (baicalein, wogonin, oroxylin A) and glycosides (baicalin, wogonoside, oroxylin A-7-glucuronide). All six flavones are pharmacologically active and show great potential in the treatment of inflammation, cancers and virus-related diseases. The current review covers the preparation of the herb Radix Scutellariae, quantification of its major bioactive ingredients, and pharmacological effects of the proposed six bioactive flavones. In addition, this review summarizes the pharmacokinetic profiles of the bioactive flavones reported so far that could be used for further improvement of their pharmacokinetic study. Moreover, due to abundant co-occurring bioactive components in Radix Scutellariae, our review further documents the pharmacokinetic interactions among them. Copyright (C) 2011 John Wiley & Sons, Ltd.