Faecal short chain fatty acid pattern and allergy in early childhood
Faecal short chain fatty acid pattern and allergy in early childhood
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DOI：
10.1111/j.1651-2227.2008.01215.x
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发表时间：
2009-05-01
期刊：
影响因子：
3.8
通讯作者：
Bjorksten, Bengt
中科院分区：
文献类型：
--
作者：
Sandin, Anna;Braback, Lennart;Bjorksten, Bengt
目的：研究肠道植物群随时间的功能变化是否与4岁时的致敏和过敏症状有关。方法：1岁（n = 139）和4岁（n = 53）时粪便样本中的短链脂肪酸（SCFAs）水平与出生后前4年的皮肤点刺试验（SPT）阳性和过敏症状有关。从1岁到4岁，粪便乙酸（p < 0.01）和丙酸（p < 0.01）减少，而戊酸（p < 0.001）增加。1年时低水平的异丁酸（p = 0.01）、异戊酸（p = 0.03）和戊酸（p = 0.02）与4年时患者报告的食物过敏症状相关。阳性SPT和过敏症状在四年与低水平的粪便中的i-丁酸，i-戊酸和戊酸。在一年的年龄，婴儿，相比，没有年长的兄弟姐妹有较高的中位数水平valericacid.Conclusion：一个缓慢的功能成熟的肠道菌群，作为衡量粪便中SCFAs的水平与过敏在一年和四年。这些发现进一步支持了过敏与微生物多样性发展之间的联系。
Aim: To investigate whether functional changes of the gut flora over time were related to sensitization and allergic symptoms at four years of age.Methods: The levels of short chain fatty acids (SCFAs) in faecal samples at one (n = 139) and four (n = 53) years of age were related to the development of positive skin prick tests (SPT) and allergic symptoms during the first four years of life.Results: Faecal acetic (p < 0.01) and propionic (p < 0.01) acids decreased from one to four years of age, while valeric acid (p < 0.001) increased. Low levels of i-butyric (p = 0.01), i-valeric (p = 0.03) and valeric acids (p = 0.02) at one year were associated with questionnaire-reported symptoms of food allergy at four years. Positive SPTs and allergic symptoms at four years were associated with low faecal levels of i-butyric, i-valeric and valeric acids. At one year of age, infants with, as compared to without older siblings had higher median levels of valeric acid.Conclusion: A slow functional maturation of the gut microflora, as measured by faecal levels of SCFAs is associated with allergy both at one and four years. The findings lend further support to an association between allergy and the development of microbial diversity.