Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway
Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway
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DOI：
10.1534/genetics.111.128264
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发表时间：
2011-12-01
期刊：
影响因子：
3.3
通讯作者：
Levin, David E.
中科院分区：
文献类型：
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作者：
Levin, David E.
酵母细胞壁是一种坚固但有弹性的结构，不仅对维持细胞形状和完整性至关重要，而且对细胞周期的进展也至关重要。在生长和形态发生期间，以及响应环境挑战，细胞壁以高度调节和极化的方式重塑，这一过程主要受细胞壁完整性（CWI）信号通路的控制。该途径将细胞壁应力信号从细胞表面传递到Rho1 GTdR，Rho1 GTdR通过各种效应物动员生理反应。CWI信号传导的激活调节细胞壁的各种碳水化合物聚合物的产生，以及它们向细胞壁重塑位点的极化递送。这篇评论文章重点关注酿酒酵母中通过细胞周期和响应细胞壁应激的CWI信号传导。还讨论了该信号通路与其他有助于维持细胞壁完整性的通路的接口。
The yeast cell wall is a strong, but elastic, structure that is essential not only for the maintenance of cell shape and integrity, but also for progression through the cell cycle. During growth and morphogenesis, and in response to environmental challenges, the cell wall is remodeled in a highly regulated and polarized manner, a process that is principally under the control of the cell wall integrity (CWI) signaling pathway. This pathway transmits wall stress signals from the cell surface to the Rho1 GTPase, which mobilizes a physiologic response through a variety of effectors. Activation of CWI signaling regulates the production of various carbohydrate polymers of the cell wall, as well as their polarized delivery to the site of cell wall remodeling. This review article centers on CWI signaling in Saccharomyces cerevisiae through the cell cycle and in response to cell wall stress. The interface of this signaling pathway with other pathways that contribute to the maintenance of cell wall integrity is also discussed.