DOPAMINE-RELATED PERSONALITY-TRAITS IN PARKINSONS-DISEASE
DOPAMINE-RELATED PERSONALITY-TRAITS IN PARKINSONS-DISEASE
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DOI：
10.1212/wnl.43.3_part_1.505
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发表时间：
1993-03-01
期刊：
影响因子：
9.9
通讯作者：
FORMAN, NE
中科院分区：
文献类型：
--
作者：
MENZA, MA;GOLBE, LI;FORMAN, NE
研究表明帕金森病 (PD) 与一组特定的人格特征有关。帕金森病患者被描述为勤奋、道德严格、坚忍、严肃、不冲动，相对一致。在这项对照研究中，我们使用了最近开发的人格问卷，即克隆格的三维人格问卷，来检验以下假设：这些人格特征是多巴胺能愉悦和奖励系统受损的行为表现。我们发现，与匹配的医疗对照组相比，PD 患者的一组称为“寻求新奇”的特征显着减少（p < 0.01）。寻求新鲜感低的患者被描述为反思性的、僵化的、坚忍的、脾气暴躁的、节俭的、有序的和持久的，这些特征与帕金森病患者的临床描述相似。我们回顾了支持新奇寻求是多巴胺依赖性这一说法的证据，并表明中脑边缘多巴胺能系统的损伤导致了帕金森病患者的人格特征。
Studies suggest that Parkinson's disease (PD) is associate with a particular group of personality characteristics. With relative uniformity, PD patients are described as industrious, rigidly moral, stoic, serious, and nonimpulsive. In this controlled study, we used a recently developed personality questionnaire, Cloningers's Tridimensional Personality Questionnaire, to test the hypothesis that these personality traits are behavioral manifestations of damaged dopaminergic pleasure and reward systems. We found significantly less (p < 0.01) of a group of traits called ''novelty seeking'' in PD patients compared with matched medical controls. Patients with low novelty seeking are described as being reflective, rigid, stoic, slow-tempered, frugal, orderly, and persistent, characteristics similar to those in the clinical description of PD patients. We review evidence supporting the claim that novelty seeking is dopamine-dependent, and suggest that damage to the mesolimbic dopaminergic system causes the described personality profile of PD patients.