THE ROLE OF PROLACTIN IN THE RESTORATION OF OVARIAN FUNCTION DURING THE EARLY POST‐PARTUM PERIOD IN THE HUMAN FEMALE
THE ROLE OF PROLACTIN IN THE RESTORATION OF OVARIAN FUNCTION DURING THE EARLY POST‐PARTUM PERIOD IN THE HUMAN FEMALE
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催乳素在女性产后早期卵巢功能恢复中的作用
DOI：
10.1111/j.1365-2265.1975.tb03300.x
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发表时间：
1975
影响因子：
3.2
通讯作者：
F. Jong
中科院分区：
文献类型：
--
作者：
R. Rolland;R. Lequin;L. Schellekens;F. Jong
用放射免疫法测定10名健康妇女在妊娠晚期和产褥期至第一次月经前的血浆泌乳素、促卵泡激素（FSH）、促黄体生成素（LH）、17β雌二醇(E)和孕酮(P)水平，并在第一次月经时进行子宫内膜活检。泌乳素浓度在妊娠晚期和产后早期较高，此后下降，但在母乳喂养期间保持在30 ng/ml以上。FSH在妊娠晚期和产后第一周几乎检测不到，但在第7天至第18天恢复到正常水平。此后，在高泌乳素血症期间发现相对较高的卵泡刺激素水平。在产后2周清除人绒毛膜促性腺激素（HCG）后，所有病例的LH保持在正常周期范围以下至少28天。胎盘E和P在7天内完全清除。尽管FSH水平相对较高，但在高泌乳素血症期间，E和LH水平仍然很低。此后，E升高，LH也随之升高，说明E对LH释放有正反馈作用。在研究中观察到的5名受试者的第一次月经之前，P水平在相对较短的时间内低于正常水平，尽管子宫内膜活检仅显示晚期增生改变。
Serial plasma levels of prolactin, follicle‐stimulating hormone (FSH), luteinizing hormone (LH), 17β‐oestradiol (E) and progesterone (P) were determined by radioimmunoassay in ten healthy women during late pregnancy and puerperium until the occurrence of the first menstruation, at which moment an endometrial biopsy was taken. Prolactin concentrations, which were high during late pregnancy and the early post‐partum period, declined thereafter but remained above 30 ng/ml plasma during the period of breast‐feeding. FSH was nearly undetectable during late pregnancy and the first week post‐partum but returned to normal levels between days 7 and 18. Thereafter relatively high FSH levels were found during the period of hyperprolactinaemia. Following clearance of human chorionic gonadotrophin (HCG) during the first 2 weeks post‐partum, LH remained below the normal cyclic range in all cases for at least 28 days. Placental E and P were fully cleared within 7 days. In spite of relatively high levels of FSH, E remained low as did LH during the period of hyperprolactinaemia. Thereafter E increased followed by an increase of LH, suggesting a positive feedback of E on LH release. The first menses observed in five subjects during the study were preceded by (subnormal P levels for a relatively short period although the endometrial biopsies showed only late proliferative changes.