Circulating adiponectin concentrations in patients with congestive heart failure
Circulating adiponectin concentrations in patients with congestive heart failure
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DOI：
10.1136/hrt.2005.083345
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发表时间：
2006-10-01
期刊：
影响因子：
5.7
通讯作者：
Roth, A.
中科院分区：
文献类型：
--
作者：
George, J.;Patal, S.;Roth, A.
目的：确定脂联素浓度及其对充血性心力衰竭（CHF）患者预后的预测价值。方法：收集175例临床控制的CHF门诊患者血清及临床资料。测定血清脂联素、C反应蛋白、n端前脑利钠肽（NT-proBNP）、白细胞介素(IL) -1 β、IL-6、IL-8、IL-10、IL-12、肿瘤坏死因子a和CD-40配体的浓度。研究了脂联素与慢性心力衰竭临床严重程度的关系，以及脂联素对死亡率、慢性心力衰竭住院率或这些终点发生的预测价值。结果：CHF患者脂联素浓度显著升高。纽约心脏协会分级较高的患者血清脂联素浓度显著升高。糖尿病和CHF患者以及缺血性心肌病患者的血清脂联素浓度较低。血清脂联素浓度与年龄、NT-proBNP呈正相关，与C反应蛋白浓度呈负相关。血清脂联素高于75百分位被发现是总死亡率、心力衰竭住院或这些终点的复合两年前瞻性随访的独立预测因子。结论：脂联素在CHF患者中升高，可预测死亡率和发病率。
Objectives: To determine concentrations of adiponectin and its predictive value on outcome in a cohort of patients with congestive heart failure (CHF).Methods: Serum and clinical data were obtained for outpatients with clinically controlled CHF (n = 175). Serum concentrations of adiponectin, C reactive protein, N-terminal pro-brain natriuretic peptide (NT-proBNP), interleukin (IL) -1 beta, IL-6, IL-8, IL-10, IL-12, tumour necrosis factor a and CD-40 ligand were determined. The association of adiponectin with the clinical severity of CHF was sought as well as the predictive value of this adipokine on mortality, CHF hospitalisations or the occurrence of each of these end points.Results: Concentrations of adiponectin were significantly increased in patients with CHF. Patients with higher New York Heart Association class had significantly higher serum concentrations of adiponectin. Adiponectin serum concentrations were lower in patients with diabetes and CHF as well as in patients with ischaemic cardiomyopathy. Serum adiponectin concentration was positively associated with age and NT-proBNP but was negatively correlated with C reactive protein concentrations. Serum adiponectin above the 75th centile was found to be an independent predictor of total mortality, CHF hospitalisations or a composite of these end points over a two-year prospective follow up.Conclusion: Adiponectin is increased in CHF patients and predicts mortality and morbidity.