Studying health histories of cancer: A new model connecting cancer incidence and survival
Studying health histories of cancer: A new model connecting cancer incidence and survival
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DOI：
10.1016/j.mbs.2008.12.007
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发表时间：
2009-04-01
影响因子：
4.3
通讯作者：
Ukraintseva, Svetlana
中科院分区：
文献类型：
--
作者：
Yashin, Anatoli I.;Akushevich, Igor;Ukraintseva, Svetlana
最近的实验和流行病学研究结果提供了证据，说明致癌作用之间的联系。癌症进展和衰老。然而，现有的模型传统上只关注健康恶化的其中一个方面。在本文中，我们推导出一个新的癌症模型，该模型描述了发病年龄、疾病持续时间和个体寿命之间的关系。该模型结合了两个命中模型中使用的想法与那些在乐布拉斯多态模型的老化与恒定的过渡强度。该模型用于美国人口死亡率数据和选定癌症的SEER数据的联合分析。研究结果表明，所开发的方法能够解释健康史数据之间的联系，并提供有关癌症发生，疾病进展，其他与衰老相关的变化和死亡率机制的有用见解。该模型的进一步发展进行了讨论。(C)2009 Elsevier Inc. All rights reserved.
The results of recent experimental and epidemiological studies provide evidence on the connection between carcinogenesis. cancer progression, and aging. Existing models, however, are traditionally focused only on one of these aspects of health deterioration. In this paper, we derive a new model of cancer, which describes the connection between the ages at disease onset, the duration of disease, and life span of respective individuals. The model combines ideas used in the two hits model of carcinogenesis with those used in the Le Bras multistate model of aging with constant transition intensities. The model is used in the joint analyses of the US demographic mortality data and SEER data for selected cancers. The results show that the developed approach is capable of explaining links among health history data and provides useful insights on mechanisms of cancer occurrence, disease progression, other aging-related changes, and mortality. Further developments of this model are discussed. (C) 2009 Elsevier Inc. All rights reserved.