Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?
Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?
复制标题
认知神经表观遗传学：我们对学习和记忆分子机制理解的下一步发展？
DOI：
10.1038/npjscilearn.2016.14
复制
发表时间：
2016
影响因子：
4.2
通讯作者：
Bredy,TimothyW
中科院分区：
文献类型：
--
作者：
Marshall,Paul;Bredy,TimothyW
对学习和记忆的基本机制的完整理解仍然困扰着神经科学家。虽然已经有了许多重要的发现，但记忆如何在分子水平上编码和维持的问题仍然存在。到目前为止，这一问题一直是在分子生物学中最占主导地位的概念之一，中心法则的背景下，其结果是蛋白质为中心的记忆观。在这里，我们讨论的证据支持神经表观遗传机制的作用，这构成了动态的和可逆的，状态依赖性的修改，在各级控制细胞功能，以及它们在学习和记忆中的作用。这种神经表观遗传学观点认为，DNA、RNA和蛋白质相互影响，产生一种整体的细胞状态，有助于记忆的形成和维持，并预测了一个并行的分布式系统，用于记忆印迹的巩固、存储和检索。
A complete understanding of the fundamental mechanisms of learning and memory continues to elude neuroscientists. Although many important discoveries have been made, the question of how memories are encoded and maintained at the molecular level remains. So far, this issue has been framed within the context of one of the most dominant concepts in molecular biology, the central dogma, and the result has been a protein-centric view of memory. Here, we discuss the evidence supporting a role for neuroepigenetic mechanisms, which constitute dynamic and reversible, state-dependent modifications at all levels of control over cellular function, and their role in learning and memory. This neuroepigenetic view suggests that DNA, RNA and protein each influence one another to produce a holistic cellular state that contributes to the formation and maintenance of memory, and predicts a parallel and distributed system for the consolidation, storage and retrieval of the engram.