Relationship Between Clinical Characteristics of Polypoidal Choroidal Vasculopathy and Choroidal Vascular Hyperpermeability
Relationship Between Clinical Characteristics of Polypoidal Choroidal Vasculopathy and Choroidal Vascular Hyperpermeability
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DOI：
10.1016/j.ajo.2012.07.018
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发表时间：
2013-02-01
影响因子：
4.2
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
--
作者：
Koizumi, Hideki;Yamagishi, Tetsuya;Kinoshita, Shigeru
目的：探讨息肉样脉络膜血管病(PCV)的临床特征与吲哚青绿血管造影显示脉络膜血管高通透性的关系。设计：回顾性、连续性、介入性病例系列。方法：回顾89例PCV患者的临床资料和血管造影资料。结果：89例PCV患者中，31例(34.8%)出现脉络膜血管高通透性。有脉络膜血管高通透性的患者比无脉络膜血管高通透性的患者更易出现双侧新生血管膜(P=0.009)，且与中心性浆液性脉络膜视网膜病变(CSC)病史有显著关系(P=0.01)。在治疗后PCV的98只眼中，有脉络膜血管高渗透的34只眼的中心凹下厚度明显大于无脉络膜血管高渗透的眼(P<；.001)。然而，脉络膜血管高通透性与PCV的其他生物显微镜和血管造影表型之间没有明显的关系。对57例未治疗的PCV患者进行了每月3次的雷尼比珠单抗玻璃体内注射治疗，发现脉络膜血管高通透性的存在与第三次注射后1个月视网膜积液显著相关(P=0.01)。结论：PCV合并脉络膜高通透性的患者比无脉络膜血管高通透性的患者更易出现双侧新生血管膜、脉络膜增厚和对玻璃体内注射雷尼比单抗反应差的情况。《眼科杂志》2013；155：305-313。(C)2013年由Elsevier Inc.保留所有权利。)
PURPOSE: To investigate the relationship between the clinical characteristics of polypoidal choroidal vasculopathy (PCV) and choroidal vascular hyperpermeability seen on indocyanine green angiography.DESIGN: Retrospective, consecutive, interventional case series.METHODS: We reviewed the medical records and the angiograms of 89 patients with PCV. The relationship between choroidal vascular hyperpermeability and background factors, associated clinical manifestations, and treatment responses to intravitreal injections of ranibizumab were evaluated.RESULTS: Of the 89 patients with PCV, 31 patients (34.8%) demonstrated choroidal vascular hyperpermeability. The patients with choroidal vascular hyperpermeability more frequently showed bilateral neovascular membrane than those without choroidal vascular hyperpermeability (P = .009) and had a significant relationship with a history of central serous chorioretinopathy (CSC) (P = .01). Of the 98 eyes with treatment-nave PCV, 34 eyes with choroidal vascular hyperpermeability demonstrated significantly greater subfoveal thickness than the 64 eyes without choroidal vascular hyperpermeability (P < .001). However, no significant relationship was found between choroidal vascular hyperpermeability and the other biomicroscopic and angiographic phenotypes of PCV. Three monthly intravitreal injections of ranibizumab were performed on 57 patients with treatment-naive PCV, and the presence of choroidal vascular hyperpermeability was significantly related to the persistent retinal fluid 1 month after the third ranibizumab injection (P = .01).CONCLUSIONS: The patients with PCV associated with choroidal vascular hyperpermeability more frequently demonstrated bilateral neovascular membrane, a history of CSC, a thickened choroid, and poor responses to intravitreal injections of ranibizumab than those without choroidal vascular hyperpermeability. (Am J Ophthalmol 2013;155:305-313. (c) 2013 by Elsevier Inc. All rights reserved.)