Structural insight on processivity, human disease and antiviral drug toxicity.
Structural insight on processivity, human disease and antiviral drug toxicity.
复制标题
对持续性、人类疾病和抗病毒药物毒性的结构见解。
DOI：
10.1016/j.sbi.2010.12.001
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发表时间：
2011
影响因子：
6.8
通讯作者：
Yin,YWhitney
中科院分区：
文献类型：
--
作者：
Yin,YWhitney
DNA聚合酶γ（Poly）是一种位于细胞核内的复制酶，负责细胞器内所有的DNA合成。在结构上，人Pol γ与噬菌体T7 DNA聚合酶非常相似。可能是由于这种类似原核生物的特性，Pol γ对针对HIV逆转录酶和HCV RNA聚合酶设计的药物的抑制非常敏感。本文综述了近年来Pol γ介导的抗病毒药物毒性的结构和生化研究进展。
DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.