Precision and reliability for measurement of change in MRI lesion volume in multiple sclerosis: a comparison of two computer assisted techniques
Precision and reliability for measurement of change in MRI lesion volume in multiple sclerosis: a comparison of two computer assisted techniques
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DOI：
10.1136/jnnp.65.1.42
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发表时间：
1998-07-01
影响因子：
11
通讯作者：
Miller, DH
中科院分区：
文献类型：
--
作者：
Molyneux, PD;Tofts, PS;Miller, DH
多发性硬化症MRI病灶负荷的系列量化为监测疾病进展提供了一种有效的工具，这导致其在治疗试验中越来越多地用作结局指标。分割技术必须显示出高度的精确性和可靠性，如果它们要对随时间的微小变化作出反应。本研究评估了两个这样的技术，手动概述和轮廓的方法，在串行病变负荷quantification. Methods，16例临床确诊多发性硬化症患者进行了扫描，在基线和两年后的性能。结果：对于绝对病变体积，轮廓技术的平均变异系数（CV）为3.2%，手动勾画法为7.6%（P
Objective-The serial quantification of MRI lesion load in multiple sclerosis provides an effective tool for monitoring disease progression and this has led to its increasing use as an outcome measure in treatment trials. Segmentation techniques must display a high degree of precision and reliability if they are to be responsive to small changes over time. This study has evaluated the performance of two such techniques, the manual outlining and contour methods, in serial lesion load quantification.Methods-Sixteen patients with clinically definite multiple sclerosis were scanned at baseline and after two years. Scan analysis was performed twice, independently by three observers using each technique.Results-For the absolute lesion volumes the median intrarater coefficient of variation (CV) was 3.2% for the contour technique and 7.6% for the manual outlining method (p