Increased nitric oxide and attenuated diastolic blood pressure variability in african americans with mildly impaired renal function.
Increased nitric oxide and attenuated diastolic blood pressure variability in african americans with mildly impaired renal function.
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DOI：
10.4061/2010/137206
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发表时间：
2011-01-09
影响因子：
1.9
通讯作者：
Brown MD
中科院分区：
文献类型：
--
作者：
Diaz KM;Feairheller DL;Sturgeon KM;Veerabhadrappa P;Williamson ST;Crabbe DL;Brown MD
我们研究了一组肾功能正常或轻度受损的非裔美国人的肾功能、血压变异性（BPV）和一氧化氮（NO）之间的关系。对38名非裔美国人进行24小时动态血压监测，测量NO，并计算肾小球滤过率（GFR）。参与者被分类为肾功能正常（GFR为90 mL/min / 1.73 m2）或轻度受损（GFR为60-89 mL/min / 1.73 m2）。轻度肾功能受损组舒张期BPV明显降低。回归分析显示，在整个研究组中，GFR和舒张期BPV之间存在显著的正相关。轻度肾功能受损组血浆NO水平明显升高，且与舒张期BPV呈负相关。总之，轻度肾功能受损的非裔美国人舒张期BPV降低，这可能是NO生成增加的结果。这些结果与之前在患病人群和非黑人人群中的发现相冲突，可以为在bp缓冲机制仍然保留的情况下，在疾病状态早期研究BPV提供理论依据。
We investigated the relationship between renal function, blood pressure variability (BPV), and nitric oxide (NO) in a group of African Americans with normal or mildly impaired renal function. 24-hour ambulatory blood pressure monitoring was performed, NO measured, and glomerular filtration rate (GFR) calculated in 38 African Americans. Participants were categorized as having normal (GFR > 90 mL/min per 1.73 m2) or mildly impaired (GFR 60–89 mL/min per 1.73 m2) renal function. Diastolic BPV was significantly lower in the mildly impaired renal function group. Regression analyses revealed a significant positive association between GFR and diastolic BPV for the entire study group. Plasma NO levels were significantly higher in the mildly impaired renal function group and negatively correlated with diastolic BPV. In conclusion, diastolic BPV was reduced in African Americans with mildly impaired renal function, which may be the result of increased NO production. These results conflict with previous findings in diseased and nonblack populations and could provide rationale for studying BPV early in the disease state when BP-buffering mechanisms are still preserved.