Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrix-producing and spindle cell carcinomas
Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrix-producing and spindle cell carcinomas
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DOI：
10.1039/g6ctr8mdtfuw19xv
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发表时间：
2003-08-01
影响因子：
3.5
通讯作者：
Gatalica, Z
中科院分区：
文献类型：
--
作者：
Popnikolov, NK;Ayala, AG;Gatalica, Z
我们用免疫组织化学方法比较了乳腺良性肌上皮瘤（腺肌瘤[AMEs]）和乳腺化生基质瘤（MMP-CA）和梭形细胞癌（MSC-CA）；帮助肌上皮细胞（MECs）一致表达细胞角蛋白、α -平滑肌肌动蛋白（SMA）、肌球蛋白、S-100、CD10和massin。他们的波形蛋白呈不同程度的阳性，上皮膜抗原（EMA）、类固醇受体、p53和HER-2/neu呈阴性。AMEs的MECs较少表达CD10（4/8[50%]）和肌球蛋白（618[75%]），但经常获得腔细胞的特征，如表达EMA（518[63%]）和类固醇受体（5/8[63%]）。AMEs未见p53或HER-2/neu异常表达。MMP-CA和MSC-CA在细胞角蛋白、vimentin、S-100、maspin和HER-2/neu的表达与AMEs相似。MMP-CAs表达α - sma（2/8[25%]）和肌球蛋白（2/7[29%]）较少，缺乏雌激素受体（0/9[0%]）。mscs - cas一致为CD10+(4/4[100%])，而肌凝蛋白（0/3[0%]）未表达。p53在MMP-CAs（4/8[50%]）和MSC-CAs（1/3[33%]）中多见过表达。乳腺良性肌上皮性肿瘤与正常mec的免疫表型不同；可能需要一组免疫组织化学标记来确定其肌上皮起源。类似的肌上皮表型改变也是乳腺化生癌的特征。癌基因或反基因（如p53）的异常表达可能比经典肌上皮标记物的表达更有助于区分这些实体。
We immnohistochemically compared benign in myoepithelial tumors (adenomyoepitheliomas [AMEs]) and metaplastic matrix-producing (MMP-CA) and spindle cell (MSC-CA) carcinomas of the breast to identifi; help myoepithelial cells (MECs) consistently expressed cytokeratin, alpha-smooth muscle actin (SMA), myosin, S-100, CD10, and maspin. They were variably positive for vimentin and negative for epithelial membrane antigen (EMA), steroid receptors, p53, and HER-2/neu. MECs in AMEs less frequently expressed CD10 (4/8 [50%]) and myosin (618 [75%]) but frequently acquired characteristics of luminal cells, such as expression of EMA (518 [63%]) and steroid receptors (5/8 [63%]). No abnormal p53 or HER-2/neu expression was seen in AMEs. MMP-CA and MSC-CA were similar to AMEs in cytokeratin, vimentin, S-100, maspin, and HER-2/neu expression. MMP-CAs expressed less alpha-SMA (2/8 [25%]) and myosin (2/7 [29%]) and lacked estrogen receptor (0/9 [0%]). MSC-CAs were consistently CD10+ (4/4 [100%]) yetfailed to express myosin (0/3 [0%]). p53 overexpression was seen frequently in MMP-CAs (4/8 [50%]) and MSC-CAs (1/3 [33%]).Benign myoepithelial mammary tumors differ immunophenotypically from normal MECs; a panel of immunohistochemical markers may be required to establish their myoepithelial origin. A similarly altered myoepithelial phenotype also is characteristic of metaplastic mammary carcinomas. The abnormal expression of oncogenes or antioncogenes, such as p53, may be more useful for distinguishing between those entities than the expression of the classic myoepithelial markers.