ESCHERICHIA-COLI RIBOSOMAL-PROTEIN S8 FEEDBACK REGULATES PART OF SPC OPERON
ESCHERICHIA-COLI RIBOSOMAL-PROTEIN S8 FEEDBACK REGULATES PART OF SPC OPERON
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DOI：
10.1038/289089a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
NOMURA, M
中科院分区：
文献类型：
--
作者：
DEAN, D;YATES, JL;NOMURA, M
在大肠在大肠杆菌中，编码52种核糖体蛋白（R蛋白）的基因被组织成位于细菌基因组不同区域的许多转录单位。r-蛋白基因的表达是平衡的，使得个体r-蛋白合成速率响应于变化的环境条件而协调变化，并且细胞池中不存在显著量的游离r-蛋白。测试了通过反馈调节机制平衡调节r蛋白基因表达的模型。S8在体内和体外的反馈调节特性表明该蛋白调节spc操纵子的一部分。
In E. coli the genes coding for the 52 ribosomal proteins (r-proteins) are organized into a number of transcription units located at various regions on the bacterial genome. The expression of r-protein genes is balanced so that individual r-protein synthesis rates change coordinately in response to changing environmental conditions, and significant amounts of free r-proteins do not exist in the cellular pool. A model suggested for the balanced regulation of r-protein gene expression, by a feedback regulatory mechanism was tested. The feedback regulatory properties of S8 in vivo and in vitro, indicate that the protein regulates a part of the spc operon.