Evolving EMRSA-15 epidemic in Singapore hospitals
Evolving EMRSA-15 epidemic in Singapore hospitals
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DOI：
10.1099/jmm.0.46950-0
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发表时间：
2007-03-01
影响因子：
3
通讯作者：
Koh, Tse-Hsien
中科院分区：
文献类型：
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作者：
Hsu, Li-Yang;Loomba-Chlebicka, Nichi;Koh, Tse-Hsien
本研究的目的是确定EMRSA-15在新加坡医院的传播程度。对2005年5月从新加坡5家急症护理公立医院收集的197株非重复耐甲氧西林金黄色葡萄球菌（MRSA）分离株进行分子分析，结果显示66株（33.5%）为EMRSA-15，121株（61.4%）属于地方性多重耐药ST 239克隆。卫生保健相关MRSA的两个主要克隆的中位和模式万古霉素MIC相对较高，为2.0 μ g ml（-1）。从2006年上半年收集的后续实验室监测数据证实，EMRSA-15克隆数量不断增加-占当地医院分离的所有MRSA的25.0%至66.1%-取代了全岛的ST 239克隆。
The aim of this study was to determine the extent of EMRSA-15 spread in hospitals in Singapore. Molecular analysis of 197 non-duplicate meticillin-resistant Staphylococcus aureus (MRSA) isolates collected from five acute care public hospitals in Singapore in May 2005 revealed that 66 (33.5%) were EMRSA-15 while 121 (61.4%) belonged to the endemic multidrug-resistant ST239 clone. Median and mode vancomycin MIC; for both major clones of health-care-associated MRSA were relatively high at 2.0 mu g ml(-1). Subsequent laboratory surveillance data collected from the first half of 2006 confirmed increasing numbers of the EMRSA-15 clone - ranging from 25.0 to 66.1% of all MRSA isolated in local hospitals-replacing the ST239 clone island-wide.