Comparison of metal release from various metallic biomaterials in vitro
Comparison of metal release from various metallic biomaterials in vitro
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DOI：
10.1016/j.biomaterials.2004.02.005
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发表时间：
2005-01-01
期刊：
影响因子：
14
通讯作者：
Gotoh, E
中科院分区：
文献类型：
--
作者：
Okazaki, Y;Gotoh, E
为了研究各种基体和合金元素的体外金属释放量，将SUS316L不锈钢、Co-Cr-Mo铸造合金、商业纯Ti 2级以及Ti-6Al-4V、无V Ti-6Al-7Nb和Ti-15Zr-4Nb-4Ta合金浸入各种溶液中，即α-介质、PBS(-)、小牛血清、 0.9% NaCl、人工唾液、1.2 质量% L-半胱氨酸、1 质量% 乳酸和 0.01 质量% HCl 7 d。在所有溶液中，Co-Cr-Mo铸造合金中Co释放量的差异相对较小。 a-培养基、PBS(-)、小牛血清、0.9% NaCl和人工唾液中Ti的释放量远低于1.2% L-CySteine、1%乳酸和0.01% HCl中的Ti释放量。 SUS316L不锈钢释放的Fe量随着pH值的增加而线性减少。另一方面，Ti材料释放的Ti量随着pH值的降低而增加，并且在pH值约为4或更高时显着减弱。随着pH值的增加，不锈钢中Ni的释放量逐渐减少。随着pH值的增加，Ti-6Al-4V和Ti-W-7M合金中Al的释放量逐渐减少。在小牛血清、PBS(-)、人工唾液、1%乳酸、1.2%L-半胱氨酸和0.01%HCl中观察到少量V释放。在所有溶液中，Ti-15Zr-4Nb-4Ta合金中Ti的释放量均小于Ti-6Al-4V和Ti6-Al-7Nb合金中的Ti释放量。特别是，在1%乳酸、1.2%L-半胱氨酸和0.01%HCl中，其含量约为30%或更少。 (Zr+Nb+Ta)的释放量也显着低于(Al+Nb)或(Al+V)的释放量。因此，Ti-15Zr-4Nb-4Ta合金具有较低的体外金属释放量，被认为有利于长期植入。 (C) 2004 Elsevier Ltd. 保留所有权利。
To investigate the metal release of each base and alloying elements in vitro, SUS316L stainless steel, Co-Cr-Mo casting alloy, commercially pure Ti grade 2, and Ti-6Al-4V, V-free Ti-6Al-7Nb and Ti-15Zr-4Nb-4Ta alloys were immersed in various solutions, namely, alpha-medium, PBS(-), calf serum, 0.9% NaCl, artificial saliva, 1.2 mass% L-Cysteine, 1 mass% lactic acid and 0.01 mass% HCl for 7 d. The difference in the quantity of Co released from the Co-Cr-Mo casting alloy was relatively small in all the solutions. The quantities of Ti released into a-medium, PBS(-), calf serum, 0.9% NaCl and artificial saliva were much lower than those released into 1.2% L-CySteine, 1% lactic acid and 0.01% HCl. The quantity of Fe released from SUS316L stainless steel decreased linearly with increasing pH. On the other hand, the quantity of Ti released from Ti materials increased with decreasing pH, and it markedly attenuated at pHs of approximately 4 and higher. The quantity of Ni released from stainless steel gradually decreased with increasing pH. The quantities of Al released from the Ti-6Al-4V and Ti-W-7M alloys gradually decreased with increasing pH. A small V release was observed in calf serum, PBS(-), artificial saliva, 1% lactic acid, 1.2% L-cysteine and 0.01% HCl. The quantity of Ti released from the Ti-15Zr-4Nb-4Ta alloy was smaller than those released from the Ti-6Al-4V and Ti6-Al-7Nb alloys in all the solutions. In particular, it was approximately 30% or smaller in 1% lactic acid, 1.2% L-cysteine and 0.01% HCl. The quantity of (Zr + Nb + Ta) released was also considerably lower than that of (Al + Nb) or (Al + V) released. Therefore, the Ti-15Zr-4Nb-4Ta alloy with its low metal release in vitro is considered advantageous for long-term implants. (C) 2004 Elsevier Ltd. All rights reserved.