ANTIBODIES TO EPSTEIN-BARR VIRAL-ANTIGENS IN FAMILIAL RHEUMATOID-ARTHRITIS
ANTIBODIES TO EPSTEIN-BARR VIRAL-ANTIGENS IN FAMILIAL RHEUMATOID-ARTHRITIS
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DOI：
10.1007/bf02943612
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发表时间：
1989-08-01
影响因子：
2.1
通讯作者：
GREALLY, J
中科院分区：
文献类型：
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作者：
MCDERMOTT, M;MOLLOY, M;GREALLY, J
对29个有两个或两个以上一级亲属患有类风湿关节炎(RA)的家系成员进行了EB病毒(EBV)血清抗体检测。对这些患者进行了临床活动评估，并记录了他们的治疗情况。在患者和受影响亲属中发现的血清阳性个体比例高于未受影响的人群。病毒衣壳抗原(VCA)抗体滴度在患者和受累亲属中往往较高。在那些存在早期抗原(EA)抗体的个体中，对Epstein-Barr核抗原(ENBA)的抗体滴度较低。结果提示，某些RA患者可能存在免疫调节缺陷，导致EBV表达增强。
Serum antibodies to Epstein-Barr virus (EBV) were measured in members of twenty-nine families in which two or more first degree relatives had rheumatoid arthritis (RA). These patients were assessed clinically for activity of disease and their treatment recorded. A higher proportion of seropositive individuals was found among patients and affected kindred than among the non-affected groups. Antibody titres to Viral Capsid Antigen (VCA) tended to be higher in patients and affected kindred. In those individuals in whom antibody to Early Antigen (EA) was present there was a lower titre of antibody to Epstein-Barr Nuclear Antigen (ENBA). The results suggest that an immunoregulatory defect may exist in some patients with RA which allows for enhanced expression of EBV.