Trained immunity - basic concepts and contributions to immunopathology.
Trained immunity - basic concepts and contributions to immunopathology.
复制标题
受过训练的免疫力 - 免疫病理学的基本概念和贡献。
DOI：
10.1038/s41581-022-00633-5
复制
发表时间：
2023-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
训练性免疫是先天免疫反应的一种功能状态，其特征是先天免疫细胞的长期表观遗传重新编程。这一概念起源于传染病领域--通过感染或接种来训练先天免疫细胞，如单核细胞、巨噬细胞和/或自然杀伤细胞，在重新刺激后增强对微生物病原体的免疫反应。虽然最初报道的是循环中的单核细胞和组织巨噬细胞(称为外周训练免疫)，但后来的发现表明，骨髓中的免疫前体细胞也可以训练(即中枢训练免疫)，这解释了疫苗接种对异种感染的长期先天免疫介导的保护作用。尽管训练有素的免疫有助于抵御感染，但内源性刺激对其不适当的诱导也可能导致异常炎症。例如，在系统性红斑狼疮和系统性硬化症中，训练有素的免疫力可能会促进炎症活动，从而促进疾病的进展。在器官移植中，训练性免疫与急性排斥和抑制训练性免疫有关，从而延长了同种异体移植物的存活时间。这一新概念有助于更好地理解不同病理条件下先天免疫反应的参与情况，并为针对先天免疫系统的表观遗传和代谢途径的治疗方法和治疗策略的开发提供了新的框架。训练性免疫是指在先天免疫细胞中形成免疫记忆。在这里，作者检查了训练有素的免疫的基本特征，以及它在涉及肾脏的免疫病理学中的作用和潜在的治疗靶向。训练性免疫是先天免疫系统的一种功能状态，其特征是与强大的免疫反应相关的细胞的长期表观遗传和代谢重新编程。实验和临床研究表明，外源性病原体相关分子模式和内源性危险相关分子模式诱导训练性免疫。训练性免疫是先天免疫系统对继发感染的一种功能性适应，但在自身免疫等情况下会导致异常的炎症活动。由于缺血-再灌注损伤和器官移植引起的无菌炎症诱导训练免疫并加速同种异体移植排斥反应。治疗抑制训练性免疫(例如，在自身免疫或移植中)或诱导其(例如，在感染或癌症中)是治疗免疫相关疾病的有希望的策略。
Trained immunity is a functional state of the innate immune response and is characterized by long-term epigenetic reprogramming of innate immune cells. This concept originated in the field of infectious diseases — training of innate immune cells, such as monocytes, macrophages and/or natural killer cells, by infection or vaccination enhances immune responses against microbial pathogens after restimulation. Although initially reported in circulating monocytes and tissue macrophages (termed peripheral trained immunity), subsequent findings indicate that immune progenitor cells in the bone marrow can also be trained (that is, central trained immunity), which explains the long-term innate immunity-mediated protective effects of vaccination against heterologous infections. Although trained immunity is beneficial against infections, its inappropriate induction by endogenous stimuli can also lead to aberrant inflammation. For example, in systemic lupus erythematosus and systemic sclerosis, trained immunity might contribute to inflammatory activity, which promotes disease progression. In organ transplantation, trained immunity has been associated with acute rejection and suppression of trained immunity prolonged allograft survival. This novel concept provides a better understanding of the involvement of the innate immune response in different pathological conditions, and provides a new framework for the development of therapies and treatment strategies that target epigenetic and metabolic pathways of the innate immune system. Trained immunity refers to the development of immunological memory in innate immune cells. Here, the authors examine the basic features of trained immunity, as well as its role and potential therapeutic targeting in immunopathologies that involve the kidney. Trained immunity is a functional state of the innate immune system that is characterized by long-term epigenetic and metabolic reprogramming of cells associated with potent immune responses. Experimental and clinical studies have demonstrated that exogenous pathogen-associated molecular patterns and endogenous danger-associated molecular patterns induce trained immunity. Trained immunity is a functional adaptation of the innate immune system against secondary infections, but can lead to aberrant inflammatory activity in conditions such as autoimmunity. Sterile inflammation owing to ischaemia–reperfusion injury and organ transplantation induces trained immunity and precipitates allograft rejection. Therapeutic inhibition of trained immunity (for example, in autoimmunity or transplantation) or its induction (for example, in infections or cancer) are promising strategies for treating immunity-related diseases.
登录
查看更多内容
Dectin-1介导β-葡聚糖的生物学作用。
DOI：
10.1084/jem.20021890
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brown GD;Herre J;Williams DL;Willment JA;Marshall AS;Gordon S
通讯作者：
Gordon S
影响因子：
64.5
作者：
Bekkering, Siroon;Arts, Rob J. W.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
30.5
作者：
Aegerter, Helena;Kulikauskaite, Justina;Wack, Andreas
通讯作者：
Wack, Andreas
DOI：
10.1038/s41581-022-00617-5
发表时间：
2022-11
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1084/jem.20102049
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bulua AC;Simon A;Maddipati R;Pelletier M;Park H;Kim KY;Sack MN;Kastner DL;Siegel RM
通讯作者：
Siegel RM