Bone marrow-derived lung epithelial cells.
Bone marrow-derived lung epithelial cells.
复制标题
DOI：
10.1513/pats.200803-031aw
复制
发表时间：
2008-08-15
期刊：
影响因子：
--
通讯作者：
Krause, Diane S
中科院分区：
文献类型：
--
作者：
Krause, Diane S
骨髓来源的细胞可以呈现上皮细胞的表型，并在多个器官中表达上皮特异性基因。在这里，我们集中在最近的数据在成人肺骨髓来源的上皮细胞的外观。这些发现引起了极大的怀疑，因为在大多数情况下，骨髓来源的上皮细胞非常罕见，起源的骨髓细胞尚不清楚，检测技术需要改进，并且似乎有多种机制发生这种情况。最近的研究集中在这些问题上。一旦这些重要的问题得到解决，将需要对这些细胞的功能进行进一步的研究，以确定这种植入是否具有任何临床意义-无论是有益的还是有害的。
Bone marrow-derived cells can take on the phenotype of epithelial cells and express epithelial-specific genes in multiple organs. Here, we focus on recent data on the appearance of marrow-derived epithelial cells in the adult lung. These findings have garnered significant skepticism because in most cases marrow-derived epithelial cells are very rare, the marrow cell of origin is not known, the techniques for detection have needed improvement, and there seem to be multiple mechanisms by which this occurs. Recent studies have focused on these concerns. Once these important concerns are addressed, further studies on the function(s) of these cells will need to be performed to determine whether this engraftment has any clinical significance-either beneficial or detrimental.