Dose-response of prolactin and thyrotropin to N3im-methyl-thyrotropin releasing hormone in euthyroid men.
Dose-response of prolactin and thyrotropin to N3im-methyl-thyrotropin releasing hormone in euthyroid men.
复制标题
甲状腺功能正常的男性催乳素和促甲状腺素对 N3im-甲基促甲状腺素释放激素的剂量反应。
DOI：
10.1210/jcem-43-4-856
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
C. Baugh
中科院分区：
文献类型：
--
作者：
J. Sowers;J. Hershman;H. Carlson;A. Pekary;A. Reed;M. G. Nair;C. Baugh
The synthetic N3im-methyl analogue of thyrotropin releasing hormone (methyl-TRH) was administered intravenously to 15 euthyroid men, ages 36-62, in graded doses from 6.25 mug to 500 mug in order to establish the range of response of prolactin (PRL), TSH, T3 and T4 to various doses of methyl-TRH. There was a dose-related rise in serum TSH, PRL, T3, and T4 which gave a nearly linear relationship when the integrated area of response was used as an index of response to the various doses of methyl-TRH. All 15 men had a clear elevation in TSH, PRL, T3 and T4 following the lowest dose of methyl-TRH TESTED (6.25 mug). There was considerable variability in the response to methyl-TRH among the individuals. One hundred mug of methyl-TRH gave a maximum TSH response; a 25 mug dose elicited a maximum PRL response.
