Lymphatic drainage and tumour prevalence in the breast: a statistical analysis of symmetry, gender and node field independence.
Lymphatic drainage and tumour prevalence in the breast: a statistical analysis of symmetry, gender and node field independence.
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DOI：
10.1111/j.1469-7580.2011.01362.x
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发表时间：
2011-06-01
影响因子：
2.4
通讯作者：
Reynolds, Hayley M
中科院分区：
文献类型：
--
作者：
Blumgart, Evan I;Uren, Roger F;Reynolds, Hayley M
目前对引流乳房的淋巴管的理解是有争议的，尽管它在乳腺癌扩散中的重要性是众所周知的。同样，关于乳腺原发性肿瘤空间分布的知识也很有限。本研究旨在检验该领域的常见假设，包括：（i）乳房淋巴引流和肿瘤患病率在身体的左右两侧对称，（ii）男性和女性具有相同的引流模式和肿瘤患病率，以及（iii）乳房中的淋巴引流独立于不同的淋巴结区域。这项研究使用了来自2304名在澳大利亚悉尼RPAH医疗中心接受治疗的乳腺癌患者的淋巴结造影数据。淋巴引流和肿瘤分布的对称性以及性别差异使用Fisher精确检验进行了测试。使用Fisher精确检验评估引流独立性，并使用多变量概率单位模型检验引流相关性。结果表明，乳房可能具有对称的淋巴引流和肿瘤患病率，并且男性和女性之间没有显著差异。此外，结果表明，乳房的直接淋巴引流可能是独立的节点字段之间。总的来说，这些结果有助于我们进一步了解淋巴解剖和乳腺肿瘤的分布。
Current understanding of the lymphatics draining the breast is controversial, despite its known importance in the spread of breast cancer. Similarly, knowledge regarding the spatial distribution of primary tumours in the breast is limited. This study sought to test commonly held assumptions in this field, including: (i) that breast lymphatic drainage and tumour prevalence are symmetric between the left and right sides of the body, (ii) that males and females have the same drainage patterns and tumour prevalences, and (iii) that lymphatic drainage in the breast occurs independently to different node fields. This study has used lymphoscintigraphy data from 2304 breast cancer patients treated at the RPAH Medical Centre, Sydney, Australia. Symmetry of lymphatic drainage and tumour distribution as well as gender differences were tested using Fisher's exact test. Drainage independence was assessed using Fisher's exact test, and a multivariate probit model was used to test for drainage correlations. Results showed that the breasts are likely to have symmetric lymphatic drainage and tumour prevalence, and that there is no significant difference between males and females. Furthermore, results showed that direct lymphatic drainage of the breasts is likely to be independent between node fields. Collectively, these results serve to further our understanding of lymphatic anatomy and the distribution of tumours in the breast.