Most sleep does not serve a vital function: Evidence from Drosophila melanogaster
Most sleep does not serve a vital function: Evidence from Drosophila melanogaster
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DOI：
10.1126/sciadv.aau9253
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发表时间：
2019-02-01
期刊：
影响因子：
13.6
通讯作者：
Gilestro, Giorgio F.
中科院分区：
文献类型：
--
作者：
Geissmann, Quentin;Beckwith, Esteban J.;Gilestro, Giorgio F.
睡眠似乎是动物王国中普遍存在的保守现象，但这种显着的进化保守性是否是基本生命功能的基础仍然是一个悬而未决的问题。使用基于机器学习的视频跟踪技术，我们对果蝇（Drosophila melanogaster）的睡眠进行了详细的高通量分析，再加上终身慢性和特定的睡眠限制。我们的研究结果表明，一些野生型果蝇在基线条件下实际上是不眠的，完全的，强制的睡眠限制不一定是野生型果蝇的致命治疗。黑腹菌我们还表明，昼夜节律驱动，而不是稳态调节，是苍蝇睡眠压力的主要贡献者。这些结果为睡眠在果蝇中的生物学作用提供了一个新的视角，并可能在其他物种中发挥作用。
Sleep appears to be a universally conserved phenomenon among the animal kingdom, but whether this notable evolutionary conservation underlies a basic vital function is still an open question. Using a machine learning-based video-tracking technology, we conducted a detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a lifelong chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type D. melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. These results offer a new perspective on the biological role of sleep in Drosophila and, potentially, in other species.