Weight gain and recurrence in idiopathic intracranial hypertension A case-control study
Weight gain and recurrence in idiopathic intracranial hypertension A case-control study
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DOI：
10.1212/wnl.0b013e3182190f51
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发表时间：
2011-05-01
期刊：
影响因子：
9.9
通讯作者：
Liu, G. T.
中科院分区：
文献类型：
--
作者：
Ko, M. W.;Chang, S. C.;Liu, G. T.
目的：探讨体重增加是否与特发性高颅压(IIH)复发有关。方法：回顾1993-2009年间在两所大学医院收治的成人IIH患者的病历，以确定有无复发。对确诊时和随后就诊时有记录的身高和体重的患者进行了研究。用Wilcoxon秩和检验比较复发和未复发患者组的平均体重指数(BMI)和体重变化百分比。结果：50例IIH患者进入分析，26例IIH复发，24例未复发。复发患者复发时的BMI高于确诊时的BMI(p=0.02，符号等级检验)。与无复发的患者(-0.75 kg/m(2)[-35至3.6]，p=0.0009，Wilcoxon秩和检验)相比，他们还显示出在初始缓解和复发之间体重增加的程度(体重指数变化+2.0 kg/m(2)[-1.5至10.8])。无复发者体重稳定(0%[95%CI-9.6%~10.1%])，而复发者体重增加6%(-3.5%~40.2%，p=0.005)，体重指数平均增加1.3 kg/m(2)/年vs-0.96 kg/m(2)/年。应建议IIH缓解的患者体重增加可能是IIH复发的一个危险因素。神经病学(R)2011；76：1564-1567
Objective: To determine whether weight gain is associated with recurrence in idiopathic intracranial hypertension (IIH).Methods: Medical records of adult patients with IIH seen between 1993 and 2009 at 2 university hospitals were reviewed to identify those with and without recurrence. Patients with documented height and weight at presentation and at subsequent visits were studied. The Wilcoxon rank sum test was used to compare mean body mass index (BMI) and percent weight change between the groups of patients with recurrence and without recurrence. The signed-rank test was used for comparing BMI within groups at the various time points.Results: Fifty women with IIH were included in the analyses: 26 had IIH recurrence and 24 did not. Patients with recurrence had greater BMI at the time of recurrence compared to BMI at diagnosis (p = 0.02, signed-rank test). They also demonstrated a greater degree of weight gain between initial resolution and recurrence (BMI change + 2.0 kg/m(2) [-1.5 to 10.8]) compared to patients without recurrence (-0.75 kg/m(2) [-35 to 3.6], p = 0.0009, Wilcoxon rank sum test). Patients without recurrence demonstrated stable weights (0% [95% Cl -9.6 to 10.1%]), while patients with recurrence demonstrated a 6% weight gain ([-3.5 to 40.2%], p = 0.005), with an average rate of BMI gain of 1.3 kg/m(2)/year vs -0.96 kg/m(2)/year in those without recurrence.Conclusion: Patients with IIH recurrence had significant increases in BMI compared to patients without recurrence in this cohort. Patients with resolved IIH should be advised that weight gain may be a risk factor for IIH recurrence. Neurology (R) 2011;76:1564-1567