Changes in extracellular brain ascorbate in rat striatum in response to administration of non-volatile anaesthetic agents.

Changes in extracellular brain ascorbate in rat striatum in response to administration of non-volatile anaesthetic agents.
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大鼠纹状体中细胞外脑抗坏血酸响应非挥发性麻醉剂的变化。

DOI:
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发表时间:
1997
影响因子:
9.8
通讯作者:
M. Fillenz
M. Fillenz
中科院分区:
医学1区
文献类型:
--
作者:
M. Miele;M. Fillenz

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我们使用恒电位体内伏安法来测量大鼠纹状体抗坏血酸对几种非挥发性麻醉剂的反应。异丙酚和戊巴比酮可增强gaba介导的神经元抑制,将抗坏血酸电流分别降低至对照组的27.0% (SEM 7.4%)和46%(6)%。水合氯醛、地西泮单用或与氯胺酮联用、芬太尼-氟尼松联用咪达唑仑对抗坏血酸电流无影响。
We used constant potential in vivo voltammetry to measure changes in striatal ascorbate in the rat in response to i.p. administration of several non-volatile anaesthetics. Propofol and pentobarbitone, which enhance GABA-mediated neuronal inhibitions, decreased ascorbate current to 27.0 (SEM 7.4) % and 46 (6) % of control, respectively. Chloral hydrate, diazepam alone or with ketamine, and fentanyl-fluanisone with midazolam produced no changes in ascorbate current.
DOI: --
发表时间: 1994
期刊: The Journal of pharmacology and experimental therapeutics
影响因子: --
作者:
Zimmerman,SA;Jones,MV;Harrison,NL
通讯作者: Harrison,NL