Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population
Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population
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ALDH2 基因功能性单核苷酸多态性与原发性高血压的关联取决于中国汉族人群的饮酒行为
DOI：
10.1038/jhh.2012.15
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发表时间：
2013-03-01
影响因子：
2.7
通讯作者：
Zhu, D.
中科院分区：
文献类型：
--
作者：
Wang, Y.;Zhang, Y.;Zhu, D.
饮酒是原发性高血压（EH）和心血管疾病发生的重要环境因素。一些流行病学研究调查了高血压和乙醛脱氢酶2（ALDH 2）基因型之间的关联，但结果不一致。本研究的目的是评估中国汉族人群饮酒行为对ALDH 2-EH关系的可能影响。共纳入1098名无血缘关系的EH患者和1021名中国汉族对照者。我们通过血液化学分析来评估三个标签单核苷酸多态性对血压（BP）和血脂水平的影响。rs671鸟嘌呤/腺嘌呤基因型（OR = 0.45，95% CI：0.28-0.74）和A等位基因（OR = 0.55，95% CI：0.36-0.85）与饮酒者EH的发病风险降低有关。此外，rs671基因型在相同的饮酒依赖模式下影响血压、甘油三酯（TG）水平和高密度脂蛋白胆固醇（HDL-C）水平。携带A等位基因的饮酒者显示出较低的收缩压（β =-0.16，P = 0.001）和TG水平（β =-0.14，P = 0.004）以及较高的HDL-C水平（β = 0.11，P = 0.019），但在不饮酒者中未观察到这种关联。总之，我们提出的证据表明，rs671在ALDH 2基因与高血压的易感性，血压升高和血脂紊乱的饮酒者，但不饮酒者。rs671在EH患者血压和血脂水平变化中的作用有待进一步研究。Journal of Human Hypertension（2013）27，181-186; doi：10.1038/jhh.2012.15; 2012年5月3日在线发表
Alcohol consumption is an important environmental factor in the development of essential hypertension (EH) and cardiovascular disease. Several epidemiological studies have investigated the association between hypertension and acetaldehyde dehydrogenase 2 (ALDH2) genotype, although the results are inconsistent. The aim of the present study was to evaluate the possible effect of drinking behavior on the ALDH2-EH relationship in a Chinese Han population. A total of 1098 unrelated individuals with EH and 1021 controls of Chinese Han ethnicity were included. We evaluated the effect of three tag single-nucleotide polymorphisms on blood pressure (BP) and serum lipid level by blood chemical assays. The major findings were that rs671 guanine/adenine genotype (odds ratio (OR) = 0.45, 95% confidence interval (CI): 0.28-0.74) and A allele (OR = 0.55, 95% CI: 0.36-0.85) were associated with a decreased risk of EH in drinkers. In addition, the rs671 genotype influenced BP, triglyceride (TG) level and high-density lipoprotein cholesterol (HDL-C) level in the same drinking-dependent pattern. Drinkers who carried the A allele displayed lower systolic BP (beta = -0.16, P = 0.001) and TG level (beta = -0.14, P = 0.004) and higher HDL-C level (beta = 0.11, P = 0.019), but this association was not observed in nondrinkers. In summary, we present evidence for the association of rs671 in the ALDH2 gene with susceptibility to EH, increase in BP and disturbance of serum lipid profiles in drinkers, but not in nondrinkers. Further functional research is warranted to elucidate the role of rs671 in the variation of BP and lipid levels in EH. Journal of Human Hypertension (2013) 27, 181-186; doi: 10.1038/jhh.2012.15; published online 3 May 2012