Sex differences in the association between birth weight and total cholesterol. A meta-analysis
Sex differences in the association between birth weight and total cholesterol. A meta-analysis
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DOI：
10.1016/j.annepidem.2005.04.006
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发表时间：
2006-01-01
影响因子：
5.6
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Lawlor, DA;Owen, CG;Smith, GD
目得：确定是否存在性别差异之间的关联出生体重和总胆固醇later in life.METHODS：荟萃分析的研究内差异的回归系数的胆固醇对birth weight.RESULTS：共34回归系数从30个研究纳入分析;这些提供的数据33,650名男性和23,129名女性。有证据表明，与女性相比，男性的出生体重与总胆固醇之间的负相关性更强。年龄校正回归系数的汇总研究内差异为-0.03 mmol/l（-0.06，-0.01），P = 0.02，年龄和体重指数校正回归系数的汇总研究内差异为-0.04 mmol/l（-0.07，-0.02），p = 0.002。在这些荟萃分析中没有异质性的证据（p值均> 0.6）。结论：这些结果为出生体重-总胆固醇相关性的性别差异提供了一些证据。这与胎儿生长的研究一致，这些研究表明出生大小反映了女性和男性不同的生物学过程。然而，需要其他非常大的研究来证实这一发现。
PURPOSE: Determine whether a sex difference exists in the association between birth weight and total cholesterol later in life.METHODS: Meta-analysis of within study differences in regression coefficients of cholesterol on birth weight.RESULTS: A total of 34 regression coefficients from 30 studies were included in the analyses; these provided data on 33,650 males and 23,129 females. There was evidence that the inverse association between birth weight and total cholesterol was stronger in males compared to females. The pooled within-study difference in age-adjusted regression coefficients was -0.03 mmol/l (-0.06, -0.01), P = 0.02 and the pooled within-study difference in age and body mass index adjusted regression coefficients was -0.04 mmol/l (-0.07, -0.02), p = 0.002. There was no evidence of heterogeneity in these meta-analyses (both p values > 0.6).CONCLUSIONS: These results provide some evidence for a sex difference in the birth weight - total cholesterol association. This is consistent with Studies of fetal growth which suggest that birth size reflects different biological processes for females and males. However, other very large studies are required to confirm this finding.