Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment.
Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment.
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DOI：
10.1182/blood.v83.8.2023.bloodjournal8382023
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发表时间：
1994-04
期刊：
影响因子：
20.3
通讯作者：
Xunxiang Du;David A. Williams
中科院分区：
文献类型：
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作者：
Xunxiang Du;David A. Williams
IL-11是来源于构成HM的细胞的独特生长因子。尽管基于IL-6样生物活性克隆，但IL-11和IL-6具有不同的生物学特征（表1）。IL-11，像许多最近克隆的生长因子一样，对造血细胞具有多效性作用，这可能取决于它所引入的细胞因子和细胞环境。然而，一些一般性调查结果是一致的（表2）。此外，IL-11对非造血细胞（包括神经元、小肠隐窝祖细胞/干细胞和前脂肪细胞）具有显著的原发性或继发性作用。IL-11的人体试验机构将提供IL-11在常用化疗方案背景下对人类造血细胞的药理学作用的重要信息。IL-11的生理作用尚不清楚，但随着几个实验室正在进行的基因靶向实验，IL-11的生理作用将变得清晰（至少在小鼠中）。
IL-11 is a unique growth factor derived from cells making up the HM. Although cloned based on IL-6-like bioactivity, IL-11 and IL-6 have distinct biologic profiles (Table 1). IL-11, like many recently cloned growth factors, has pleiotropic effects on hematopoietic cells presumably depending on the cytokine and cellular environment into which it is introduced. However, some general findings are consistent (Table 2). In addition, IL-11 has significant effects, either primary or secondary, on nonhematopoietic cells, including neurons, small intestine crypt progenitor/stem cells, and preadipocytes. The institution of human trials with IL-11 will provide important information on the pharmacologic effects of IL-11 on human hematopoietic cells in the context of frequently used chemotherapy protocols. The physiologic role(s) of IL-11 are unknown but will become clear (at least in the mouse) with gene targeting experiments underway in several laboratories.