Profoundly Disturbed Lipoproteins in Cirrhotic Patients: Role of Lipoprotein-Z, a Hepatotoxic LDL-like Lipoprotein.
Profoundly Disturbed Lipoproteins in Cirrhotic Patients: Role of Lipoprotein-Z, a Hepatotoxic LDL-like Lipoprotein.
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DOI：
10.3390/jcm11051223
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发表时间：
2022-02-24
影响因子：
3.9
通讯作者：
Dullaart RPF
中科院分区：
文献类型：
--
作者：
van den Berg EH;Flores-Guerrero JL;Gruppen EG;Garcia E;Connelly MA;de Meijer VE;Bakker SJL;Blokzijl H;Dullaart RPF
关于肝硬化患者在原位肝移植（奥尔特）前后脂蛋白浓度和亚组分的详细信息缺乏。脂蛋白Z（Lipoprotein-Z，LP-Z）是一种具有肝毒性的高胆固醇低密度脂蛋白样脂蛋白。我们测定了肝硬化患者和奥尔特受者的脂蛋白谱，包括LP-Z，并评估了LP-Z对奥尔特等待名单的预后意义。我们对移植候选者和非移植奥尔特受者进行了分析。一个基于人群的队列被用作参考。场景是一所大学医院。通过核磁共振光谱法测定脂蛋白颗粒浓度和亚组分。与奥尔特受者（N = 372）和对照组（N = 6027）相比，在血小板减少患者（N = 130）中，大多数富含甘油三酯的脂蛋白（TRL）、LDL和高密度脂蛋白（HDL）的测量值都要低得多（p < 0.01）。在奥尔特接受者中，许多脂蛋白变量适度降低，但HDL-胆固醇，甘油三酯，TRL和HDL大小大于对照人群。在40例肝移植患者和3例奥尔特受者中可测量到LP-Z（30.8%对0.8%，p < 0.001）。具有可测量的LP-Z水平的阿尔茨海默病患者的HDL-胆固醇和颗粒浓度显著降低（p < 0.001），Child Pugh Turcotte分级和MELD评分更差。LP-Z的存在（根据年龄、性别和MELD评分调整）预示着阿尔茨海默病患者的生存率更差（HR/1 LnSD增量：1.11，95%CI 1.03-1.19，p = 0.003）。总之，动脉粥样硬化患者血浆中所有主要脂蛋白的浓度都显著降低，脂蛋白亚组分分布也发生变化。奥尔特后，这些脂蛋白异常部分逆转。LP-Z与肝硬化有关。它的存在可能会导致HDL代谢紊乱和生存率下降。
Detailed information regarding lipoprotein concentrations and subfractions in cirrhotic patients before and after orthotopic liver transplantation (OLT) is lacking. Lipoprotein-Z (LP-Z) is a recently characterised abnormal, hepatotoxic free cholesterol-rich low-density lipoprotein (LDL)-like lipoprotein. We determined the lipoprotein profiles, including LP-Z, in cirrhotic patients and OLT recipients and assessed the prognostic significance of LP-Z on the OLT waiting list. We performed analyses in cirrhotic transplant candidates and non-cirrhotic OLT recipients. A population-based cohort was used as reference. The setting was a University hospital. Lipoprotein particle concentrations and subfractions were measured by nuclear magnetic resonance spectroscopy. In the cirrhotic patients (N = 130), most measures of triglyceride-rich lipoproteins (TRL), LDL, and high-density lipoproteins (HDL) were much lower compared to the OLT recipients (N = 372) and controls (N = 6027) (p < 0.01). In the OLT recipients, many lipoprotein variables were modestly lower, but HDL-cholesterol, triglycerides, and TRL and HDL size were greater vs. the control population. LP-Z was measurable in 40 cirrhotic patients and 3 OLT recipients (30.8% vs. 0.8%, p < 0.001). The cirrhotic patients with measurable LP-Z levels had profoundly lower HDL-cholesterol and particle concentrations (p < 0.001), and worse Child Pugh Turcotte classifications and MELD scores. The presence of LP-Z (adjusted for age, sex, and MELD score) predicted worse survival in cirrhotic patients (HR per 1 LnSD increment: 1.11, 95%CI 1.03–1.19, p = 0.003). In conclusion, cirrhotic patients have considerably lower plasma concentrations of all major lipoprotein classes with changes in lipoprotein subfraction distribution. After OLT, these lipoprotein abnormalities are in part reversed. LP-Z is associated with cirrhosis. Its presence may translate in disturbed HDL metabolism and worse survival.
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影响因子：
11.1
作者：
Kappelle, P. J. W. H.;Gansevoort, R. T.;Dullaart, R. P. F.
通讯作者：
Dullaart, R. P. F.
扩展的脂质面板测定法：一种用于同时测量脂质和载脂蛋白的临床部署的高通量核磁共振方法。
影响因子：
4.5
作者：
Garcia E;Bennett DW;Connelly MA;Jeyarajah EJ;Warf FC;Shalaurova I;Matyus SP;Wolak-Dinsmore J;Oskardmay DN;Young RM;Sampson M;Remaley AT;Otvos JD
通讯作者：
Otvos JD
影响因子：
3.9
作者：
Bedi S;Garcia E;Jeyarajah EJ;Shalaurova I;Perez-Matos MC;Jiang ZG;Dullaart RPF;Matyus SP;Kirk WJ;Otvos JD;Davidson WS;Connelly MA
通讯作者：
Connelly MA
影响因子：
4.6
作者：
Laish, Ido;Braun, Marius;Ben Ari, Ziv
通讯作者：
Ben Ari, Ziv
影响因子：
3.1
作者：
Fernandez-Miranda, C;Guijarro, C;del Palacio, A
通讯作者：
del Palacio, A