Class-specific binding of two aminoacyl-tRNA synthetases to annexin, a Ca2+- and phospholipid-binding protein.
Class-specific binding of two aminoacyl-tRNA synthetases to annexin, a Ca2+- and phospholipid-binding protein.
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两种氨酰基-tRNA 合成酶与膜联蛋白（一种 Ca2 和磷脂结合蛋白）的类特异性结合。
DOI：
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发表时间：
2005
影响因子：
1.5
通讯作者：
S. Ogihara
中科院分区：
文献类型：
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作者：
T. Shirakawa;A. Nakamura;K. Kohama;M. Hirakata;S. Ogihara
膜联蛋白是一类钙/磷脂结合蛋白家族，具有多种功能。为了了解膜联蛋白在多头绒泡菌中的功能，我们寻找了它的结合蛋白。在这里，我们展示了两种新的膜联蛋白结合蛋白的存在。对这两种蛋白质的部分氨基酸序列进行同源性搜索，确定它们为氨基酰基-tRNA合成酶(ARSS)。此外，抗氨酰-tRNA合成酶的抗体与两种蛋白质中的一种发生交叉反应。我们的结果暗示了细胞内膜动力学和蛋白质翻译系统之间的相互作用，并可能为理解某些肌炎疾病的机制提供线索，这些疾病已被认为能产生抗ARSS的自身抗体。
Annexins are a family of Ca2+/phospholipid-binding proteins that have diverse functions. To understand the function of annexin in Physarum polycephalum, we searched for its binding proteins. Here we demonstrate the presence of two novel annexin-binding proteins. The homology search of partial amino acid sequences of these two proteins identified them as aminoacyl-tRNA synthetases (ARSs). Furthermore, antibody against aminoacyl-tRNA synthetases cross-reacted with one of two proteins. Our results imply the interaction between intracellular membrane dynamics and protein translation system, and may give a clue to understand the mechanism of some myositis diseases, which have been known to produce autoantibodies against ARSs.
DOI：
10.1172/jci116493
发表时间：
1993-06
期刊：
The Journal of clinical investigation
影响因子：
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作者：
I. Targoff;E. Trieu;Frederick W. Miller
通讯作者：
I. Targoff;E. Trieu;Frederick W. Miller
DOI：
10.1016/s0021-9258(19)47323-7
发表时间：
1991-09
期刊：
The Journal of biological chemistry
影响因子：
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作者：
J. Burbaum;Paul Schimmel
通讯作者：
J. Burbaum;Paul Schimmel