Transparent, elastomeric and tough hydrogels from poly(ethylene glycol) and silicate nanoparticles
Transparent, elastomeric and tough hydrogels from poly(ethylene glycol) and silicate nanoparticles
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DOI：
10.1016/j.actbio.2011.07.023
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发表时间：
2011-12-01
影响因子：
9.7
通讯作者：
Schmidt, Gudrun
中科院分区：
文献类型：
--
作者：
Gaharwar, Akhilesh K.;Rivera, Christian P.;Schmidt, Gudrun
研究了由聚乙二醇（PEG）和硅酸盐纳米颗粒（Laponite RD）制成的物理交联和共价交联的纳米复合水凝胶的结构和力学性能。可注射的纳米复合材料前体溶液可以通过光聚合共价交联。所得水凝胶是透明的，并且具有互连的孔、高伸长率和韧性。这些性质取决于水凝胶组成、聚合物-纳米颗粒相互作用和交联程度（物理和共价）。聚合物链的共价交联导致弹性网络的形成，而纳米颗粒和聚合物链之间的物理交联诱导粘弹性。在高变形下，共价键可能会断裂，但物理键会重建，并在一定程度上自我修复整个网络结构。硅酸盐的添加还增强了水凝胶的生物活性和粘附性，因为这些材料粘附到软组织以及硬表面。此外，MC 3 T3-E1小鼠前成骨细胞容易粘附并扩散在纳米复合水凝胶表面上。总的来说，诸如弹性、刚度、互连网络、粘附表面和对细胞的生物粘附的性质的组合为设计用于整形外科、颅面和牙科应用的机械强度和弹性的组织基质提供了灵感和机会。(C)2011 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
The structures and mechanical properties of both physically and covalently cross-linked nanocomposite hydrogels made from poly(ethylene glycol) (PEG) and silicate nanoparticles (Laponite RD) are investigated. Injectable nanocomposite precursor solutions can be covalently cross-linked via photopolymerization. The resulting hydrogels are transparent and have interconnected pores, high elongation and toughness. These properties depend on the hydrogel composition, polymer-nanoparticle interactions and degree of cross-linking (both physical and covalent). Covalent cross-linking of polymer chains leads to the formation of an elastic network, whereas physical cross-linking between nanoparticles and polymer chains induces viscoelastic properties. At high deformations covalent bonds may be broken but physical bonds rebuild and to some extent self-heal the overall network structure. Addition of silicate also enhances the bioactivity and adhesiveness of the hydrogel as these materials stick to soft tissue as well as to hard surfaces. In addition, MC3T3-E1 mouse preosteoblast cells readily adhere and spread on nanocomposite hydrogel surfaces. Collectively, the combinations of properties such as elasticity, stiffness, interconnected network, adhesiveness to surfaces and bio-adhesion to cells provide inspiration and opportunities to engineer mechanically strong and elastic tissue matrixes for orthopedic, craniofacial and dental applications. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.