Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: A pathological study of 1503 consecutive autopsy cases
Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: A pathological study of 1503 consecutive autopsy cases
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DOI：
10.1016/j.atherosclerosis.2012.01.003
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发表时间：
2012-04-01
期刊：
影响因子：
5.3
通讯作者：
Sawabe, Motoji
中科院分区：
文献类型：
--
作者：
Ikeda, Shinobu;Tanaka, Noriko;Sawabe, Motoji
目的：最近的全基因组关联研究已经确定了α-半乳糖苷酶（LTA）、半乳糖凝集素-2（LGALS 2）和蛋白酶体亚单位a 6型（PSMA 6）基因的多态性是心肌梗死（MI）的遗传风险因素。然而，它们对冠状动脉粥样硬化（MI的中间表型）的影响在很大程度上仍然未知。方法：我们在1503例连续尸检的日本老年患者中调查了LTA、LGALS 2和PSMA 6基因多态性与病理性冠状动脉狭窄指数（CSI）和MI严重程度之间的相关性。多态性LTA rs 1041981和LGALS 2 rs7291467与CSI相关，比值比分别为1.54（95% CI，1.17-2.01; AA + CA相对于CC）和1.62（95% CI，1.11-2.37; TT相对于CC + CT）。PSMA 6 rs 1048990与CSI无关。结论：我们的研究结果表明，LTA和LGALS 2多态性影响冠状动脉的亚临床表型，这容易发生MI。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Recent genome-wide association studies have identified polymorphisms of lymphotoxin-alpha (LTA), galectin-2 (LGALS2), and proteasome subunit a type 6 (PSMA6) genes as genetic risk factors for myocardial infarction (MI). However, their effects on coronary atherosclerosis, an intermediate phenotype of MI, remain largely unknown.Methods: We investigated the correlation between polymorphisms of the LTA, LGALS2, and PSMA6 genes and the severity of pathological coronary stenosis index (CSI) and MI in 1503 consecutive autopsy cases of Japanese elderly patients.Results: The polymorphisms LTA rs1041981 and LGALS2 rs7291467 were associated with CSI with odds ratios of 1.54 (95% CI, 1.17-2.01; AA + CA over CC) and 1.62 (95% CI, 1.11-2.37; TT over CC + CT), respectively. PSMA6 rs1048990 was not associated with CSI. None of the SNPs was associated with MI in our sample.Conclusion: Our findings indicate that the LTA and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of MI. (C) 2012 Elsevier Ireland Ltd. All rights reserved.