Cellular ion content changes during and after hyperthermia.
Cellular ion content changes during and after hyperthermia.
复制标题
热疗期间和之后细胞离子含量发生变化。
DOI：
10.1016/0006-291x(79)90600-4
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发表时间：
1979
影响因子：
3.1
通讯作者：
P. Yi
中科院分区：
文献类型：
--
作者：
P. Yi
小鼠肥大细胞瘤P815细胞在43℃孵育30分钟内，钾含量下降40%，当细胞在43℃孵育60分钟后回到37℃时，钾水平进一步下降。在41℃下孵育60分钟后，细胞内钾的变化较小(20%)。此外，在随后的37℃下孵育2小时后，几乎所有丢失的钾都能恢复。另一方面，细胞内钠水平的增加幅度远远小于钾的变化。然而，受热细胞的阳离子净损失并不会导致细胞内水分的同时减少。
The potassium (K) level in mouse mastocytoma P815 cells undergoes a 40% reduction within 30 minutes of incubation at 43°C. It decreases further when the cells return to 37°C after a 60 minute 43°C incubation. A smaller change (20%) occurs after a 60 minute incubation at 41°C. Furthermore, nearly all of the lost K recovers in two hours after a subsequent incubation at 37°C. On the other hand, the sodium level in the cells increases by an amount much smaller than the potassium changes. However, the net loss of cations from the cells undergoing hyperthermia does not induce a simultaneous reduction of intracellular water volume.