Genes and Developmental Pathways
Genes and Developmental Pathways
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基因和发育途径
DOI：
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发表时间：
1963
期刊：
影响因子：
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通讯作者：
E. Lewis
中科院分区：
文献类型：
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作者：
E. Lewis
基因控制生物体生长和发育的方式是生物学中的一个中心问题，也是目前从噬菌体到人的各种形式的研究中的一个问题。我想讨论一种利用果蝇中一系列假等位基因来解决这个问题的方法。在一些情况下，这些具有相关效应的密切相关的基因系列已经在细菌中被有益地利用，以了解更多关于基因如何控制生化途径的信息。引人注目的例子是沙门氏菌中控制组氨酸生物合成的连锁基因（Demerec和Hartman，1959;艾姆斯和Hartman，1962），或大肠杆菌中控制乳糖利用的连锁基因。coli（Jacob and Monod，1961 a，B）。可以预期，影响形态特征的假等位基因系列（例如下文所述的情况）也可以被有益地利用，以更多地了解基因如何控制发育途径。
The way in which genes control the growth and development of an organism is a central problem in biology, and one which is currently under study in diverse forms from phage to man. I would like to discuss an approach to this problem which makes use of a series of pseudoallelic genes in Drosophila. Such series of closely linked genes with related effects have, in several instances, been profitably exploited in the bacteria to learn more about how genes control biochemical pathways. Striking examples are the linked genes controlling histidine biosynthesis in Salmonella (Demerec and Hartman, 1959; Ames and Hartman, 1962), or lactose utilization in E. coli (Jacob and Monod, 1961a,b). It may be anticipated that pseudoallelic series affecting morphological traits, such as the case to be described below, can also be profitably exploited to learn more about how genes control developmental pathways.