REGULATION OF HUMORAL IMMUNITY IN RATS BY PITUITARY-HORMONES
REGULATION OF HUMORAL IMMUNITY IN RATS BY PITUITARY-HORMONES
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DOI：
10.1530/acta.0.0980506
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
HORVATH, E
中科院分区：
文献类型：
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作者：
BERCZI, I;NAGY, E;HORVATH, E
垂体切除雌性Fischer 344和Wistar-Furth大鼠对绵羊红细胞（SRBC）的一级和二级抗体反应严重受损。巯基乙醇敏感性（IgM）和巯基乙醇抗性（IgG）抗体受到类似的影响。大肠杆菌055：B5脂多糖的滴度在这些动物中也显著降低。垂体切除大鼠的抗体反应可以通过将同系垂体移植物置于肾包膜下或通过催乳素治疗来恢复。生长激素在这方面不如催乳素有效。用ACTH处理正常大鼠抑制其对SRBC的抗体形成。脑下垂体显然具有调节体液免疫反应的潜力。
Hypophysectomized female Fischer 344 and Wistar-Furth rats had severely impaired primary and secondary antibody responses to sheep red blood cells (SRBC). Mercaptoethanol-sensitive (IgM) and mercaptoethanol-resistant (IgG) antibodies were similarly affected. Titers to Escherichia coli 055:B5 lipopolysaccharide were also significantly decreased in such animals. The antibody response of hypophysectomized rats could be restored by syngeneic pituitary grafts when placed under the kidney capsule or by prolactin treatment. Growth hormone was less effective in this respect than prolactin. Treatment of normal rats with ACTH suppressed their antibody formation to SRBC. The pituitary gland apparently has the potential to regulate humoral immune responses.