Internal consistency and item-total correlation of patient-reported outcome instruments and hemophilia joint health score v2.1 in US adult people with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study.
Internal consistency and item-total correlation of patient-reported outcome instruments and hemophilia joint health score v2.1 in US adult people with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study.
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DOI：
10.2147/ppa.s141391
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发表时间：
2017
影响因子：
2.2
通讯作者：
Kempton CL
中科院分区：
文献类型：
--
作者：
Wang M;Batt K;Kessler C;Neff A;Iyer NN;Cooper DL;Kempton CL
疼痛、功能损害和生活质量研究是一项观察性横断面评估，旨在评估疼痛对美国任何严重程度的血友病（PWH）成人关节疼痛和/或出血患者的功能损害和生活质量的影响。评估疼痛、功能障碍和生活质量研究中使用的评估工具的内部一致性（IC）和项目-总体相关性（ITC）。受试者完成了5项患者报告结局工具（EQ-5D-5L和视觉模拟量表、简明疼痛量表v2简表[BPI]、国际体力活动问卷[IPAQ]、简表36健康调查v2 [SF-36 v2]和血友病活动列表[HAL]），并在常规访视期间接受了可选的物理治疗师管理的肌肉骨骼检查（血友病关节健康评分v2.1）。可靠性评估包括每个仪器的IC和ITC。共有381名成年PWH（中位年龄34岁）入组。参与者主要为白色/非西班牙裔（69.2%）; 75%患有先天性血友病A，70.5%患有重度血友病。过去6个月内共有310例受试者报告出血（平均[SD]出血次数，7.1 [13.00]）。除了HAL使用交通工具（0.58）和IPAQ总体力活动（0.51）外，IC在所采用的工具中普遍较高（Cronbach α 0.79 - 0.98）。除了IPAQ的"剧烈强度活动"项目适用于不到三分之一的参与者外，所有项目的ITC都很高（皮尔逊积差相关系数> 0.20）。ITC通常在测量血友病性关节病对活动性和疼痛的功能后果的领域/评分中最高。患者报告结局工具和血友病关节健康评分v2.1的已证实可靠性（IC/ITC）支持这些工具在美国临床和研究环境中评价成人PWH的作用。
The Pain, Functional Impairment, and Quality of Life study was an observational, cross-sectional assessment of the impact of pain on functional impairment and quality of life in adult people with hemophilia (PWH) of any severity in the USA who experience joint pain and/or bleeding. To assess internal consistency (IC) and item-total correlation (ITC) of assessment tools used in the Pain, Functional Impairment, and Quality of Life study. Participants completed 5 patient-reported outcome instruments (EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form [BPI], International Physical Activity Questionnaire [IPAQ], Short Form 36 Health Survey v2 [SF-36v2], and Hemophilia Activities List [HAL]) and underwent an optional physiotherapist-administered musculoskeletal exam (Hemophilia Joint Health Score v2.1) during routine visits. Reliability assessment included IC and ITC of each instrument. A total of 381 adult PWH (median age, 34 years) were enrolled. Participants were predominantly white/non-Hispanic (69.2%); 75% had congenital hemophilia A, and 70.5% had severe hemophilia. A total of 310 subjects reported bleeding within the past 6 months (mean [SD] number of bleeds, 7.1 [13.00]). IC was generally high across the instruments employed (Cronbach’s alpha 0.79–0.98) with the exception of HAL use of transportation (0.58) and IPAQ total physical activity (0.51). ITC was high (Pearson’s product-moment correlation coefficient >0.20) for all items except the “vigorous intensity activities” item of IPAQ, which was applicable to less than one-third of participants. The ITCs were generally highest in domains/scores that measured the functional consequences of hemophilic arthropathy on mobility and pain. The demonstrated reliability (IC/ITC) of the patient-reported outcome instruments and Hemophilia Joint Health Score v2.1 support a role for these instruments in evaluating adult PWH in US clinical and research settings.