Comparison of a reduced carbohydrate and reduced fat diet for LDL, HDL, and VLDL subclasses during 9-months of weight maintenance subsequent to weight loss.
Comparison of a reduced carbohydrate and reduced fat diet for LDL, HDL, and VLDL subclasses during 9-months of weight maintenance subsequent to weight loss.
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DOI：
10.1186/1476-511x-9-54
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发表时间：
2010-06-01
影响因子：
4.5
通讯作者：
Donnelly JE
中科院分区：
文献类型：
--
作者：
LeCheminant JD;Smith BK;Westman EC;Vernon MC;Donnelly JE
这项研究比较了超重或肥胖成人在体重显著减轻后9个月食用减碳水化合物（RC）或减脂（RF）体重维持饮食中的LDL、HDL和VLDL亚类。35名超重或肥胖中年人（21名正常对照组，14名正常对照组）完成了为期1年的体重管理临床研究。参与者在前六个月每周见一次面，之后每两周见一次。会议内容包括指导饮食、体育活动和与体重管理相关的行为改变。此外，在研究的前三个月，参与者遵循每天约2092千焦的液体极低能量饮食。随后，参与者遵循了9个月的饮食计划，目标是减少碳水化合物（~20%）或脂肪（~30%）的摄入量，并计算出维持体重的能量摄入水平。在减肥前和体重维持期间多次使用核磁共振光谱分析脂质亚类。体重维持期间各组内及组间体重变化差异无统计学意义（p < 0.05）。体重维持期间，RC组的平均LDL大小、大LDL、总HDL、大、小HDL、平均VLDL大小、大VLDL均显著升高，RF组的总HDL、大、小HDL、总VLDL、大、中、小VLDL均显著升高（p < 0.05）。大、中VLDL组*时间交互作用显著（p < 0.05）。两种饮食组的一些个别脂质亚类均有所改善。在RF组中，大、中VLDL亚类在体重维持过程中增加的程度更大。
This study compared LDL, HDL, and VLDL subclasses in overweight or obese adults consuming either a reduced carbohydrate (RC) or reduced fat (RF) weight maintenance diet for 9 months following significant weight loss. Thirty-five (21 RC; 14 RF) overweight or obese middle-aged adults completed a 1-year weight management clinic. Participants met weekly for the first six months and bi-weekly thereafter. Meetings included instruction for diet, physical activity, and behavior change related to weight management. Additionally, participants followed a liquid very low-energy diet of ~2092 kJ per day for the first three months of the study. Subsequently, participants followed a dietary plan for nine months that targeted a reduced percentage of carbohydrate (~20%) or fat (~30%) intake and an energy intake level calculated to maintain weight loss. Lipid subclasses using NMR spectroscopy were analyzed prior to weight loss and at multiple intervals during weight maintenance. Body weight change was not significantly different within or between groups during weight maintenance (p > 0.05). The RC group showed significant increases in mean LDL size, large LDL, total HDL, large and small HDL, mean VLDL size, and large VLDL during weight maintenance while the RF group showed increases in total HDL, large and small HDL, total VLDL, and large, medium, and small VLDL (p < 0.05). Group*time interactions were significant for large and medium VLDL (p > 0.05). Some individual lipid subclasses improved in both dietary groups. Large and medium VLDL subclasses increased to a greater extent across weight maintenance in the RF group.