Asteroid hyalosis in a population: The Beaver Dam Eye Study
Asteroid hyalosis in a population: The Beaver Dam Eye Study
复制标题
DOI：
10.1016/s0002-9394(01)00936-9
复制
发表时间：
2001-07-01
影响因子：
4.2
通讯作者：
Klein, BEK
中科院分区：
文献类型：
--
作者：
Moss, SE;Klein, R;Klein, BEK
目的：估计小行星透明质病的患病率，并在以人群为基础的队列中检查小行星透明质病的相关因素。方法：对1988 - 1990年威斯康星州比弗坝市43 - 86岁人口（n = 4926）进行调查。人口主要是北欧白人（99.4%）。小行星透明症是由三个标准视野的立体眼底照片确定的。结果：4747名受试者眼底照片可分级。小行星透明质症发生率为1.2%（95%可信区间为0.9 - 1.5%）。在存在小行星透明质症的受试者中，9%为双侧。随着年龄的增长，患病率从43 ~ 54岁的0.2%增加到75 ~ 86岁的2.9% （P < 0.001）。在调整年龄后，男性（1.8%）比女性（0.8%）更容易患小行星透明质症。在调整了年龄和性别后，小行星透明质症在体重较大（P = 0.02）和酒精摄入量较高（P = 0.03）的受试者中更容易出现。收缩压（P = .07）、血清胆固醇（P = .09）和血清白蛋白（P = .09）的变化趋势无统计学意义。与舒张压、高血压、糖尿病、心血管病史、高密度脂蛋白胆固醇、血清钙、吸烟、体力活动、眼压或屈光不正无显著相关性（P < 0.05）。这些关系在多变量逻辑模型中得到证实。结论：目前的研究记录了从眼底的三个摄影视野分级的人群中小行星透明症的罕见性。43岁到54岁的人没有0.2% 75岁到86岁的人没有2.9%。在调整了年龄因素后，男性更有可能出现较大的体重（P = 0.02）和较高的酒精摄入量（P = 0.03）。收缩压（P = 0.07）无显著趋势，血清胆固醇与舒张压、高血压、糖尿病、心血管疾病显著相关（P = 0.05），支持先前关于小行星透明质症与糖尿病或屈光不正相关的观察。报告的新关联（体重、酒精）的相关性仍有待确定。[J]中华眼科杂志2001；32(1):1 -7。(C) 2001年Elsevier Science Inc.版权所有)。
PURPOSE: To estimate the prevalence of asteroid hyalosis and to examine correlates of asteroid hyalosis in a population-based cohort.METHODS: The population of Beaver Dam, Wisconsin, that was 43 to 86 years of age was examined from 1988 to 1990 (n = 4926). The population is predominantly white (99.4%) northern European. Asteroid hyalosis was determined from stereoscopic fundus photographs of three standard fields.RESULTS: Fundus photographs were gradable in 4747 subjects. Asteroid hyalosis mas present in 1.2% (95% confidence interval, 0.9,1.5%). In subjects in which it was present, asteroid hyalosis was bilateral in 9%. Prevalence increased significantly (P < .001) with age from 0.2% in subjects 43 to 54 years to 2.9% in subjects 75 to 86 years. After adjusting for age, men were more likely (1.8%) to have asteroid hyalosis than women (0.8%). After adjusting for age and sex, asteroid hyalosis was significantly more likely to be found in subjects with greater body mass (P = .02) and higher alcohol consumption (P = .03). There were nonsignificant trends with systolic blood pressure (P = .07), serum cholesterol (P = .09), and serum albumin (P = .09). It was not significantly associated (P > .05) with diastolic blood pressure, hypertension, diabetes, cardiovascular disease history, high-density-lipoprotein cholesterol, serum calcium, cigarette smoking, physical activity, intraocular pressure, or refractive error. These relationships were confirmed in a multivariable logistic model.CONCLUSIONS: The current study documents the infrequency of asteroid hyalosis in the population as graded from three photographic fields of the fundus. It does not 0.2% in subjects 43 to 54 years to 2.9% in subjects 75 to 86 years. After adjusting for age, men were more likely greater body mass (P = .02) and higher alcohol consumption (P = .03). There were nonsignificant trends with systolic blood pressure (P = .07), serum cholesterol significantly associated (P > .05) with diastolic blood pressure, hypertension, diabetes, cardiovascular disease support previous observations of an association of asteroid hyalosis with diabetes or refractive error. The relevance of the new associations reported (body mass, alcohol) remains to be determined. (Am J Ophthalmol 2001;132:10-75. (C) 2001 by Elsevier Science Inc. All rights reserved).