The Neural Correlates of Emotional Memory in Posttraumatic Stress Disorder
The Neural Correlates of Emotional Memory in Posttraumatic Stress Disorder
复制标题
DOI：
10.1016/j.biopsych.2010.07.018
复制
发表时间：
2010-12-01
影响因子：
10.6
通讯作者：
Shin, Lisa M.
中科院分区：
文献类型：
--
作者：
Brohawn, Kathryn Handwerger;Offringa, Reid;Shin, Lisa M.
背景：创伤后应激障碍（PTSD）的特征是对高度情绪化事件的侵入性、慢性和痛苦的记忆。先前的研究已经强调了杏仁核的作用及其与海马体的相互作用，在健康个体中介导了对情感信息的增强记忆的效果。由于这些区域的功能完整性可能在PTSD中受到损害，本研究探讨了PTSD中情绪记忆的神经相关性。方法：我们使用功能磁共振成像和事件相关的后续记忆识别范式研究了18名PTSD患者和18名创伤暴露的非PTSD对照参与者的杏仁核和海马激活。相对于中性图片，所有受试者对负面图片的记忆增强，组间无显著差异。相对于创伤暴露的非PTSD组，PTSD组在编码负面图片和中性图片时表现出杏仁核激活过度。当分析仅包括来自随后在1周后记住的图片的数据时，这种效果更加明显。在PTSD组中，杏仁核激活程度在编码消极与中性图片与海马激活和当前PTSD症状严重程度呈正相关。创伤后应激障碍组也表现出海马体的过度激活，以应对被记住和被遗忘的负面图片。最后，海马激活与成功的编码负相对于中性pictures显着更大的PTSDgroup.Conclusions：夸张的杏仁核激活过程中编码的情绪负性刺激在PTSD症状的严重程度和海马激活。
Background: Posttraumatic stress disorder (PTSD) is marked by intrusive, chronic, and distressing memories of highly emotional events. Previous research has highlighted the role of the amygdala and its interactions with the hippocampus in mediating the effect of enhanced memory for emotional information in healthy individuals. As the functional integrity of these regions may be compromised in PTSD, the current study examined the neural correlates of emotional memory in PTSD.Methods: We used functional magnetic resonance imaging and an event-related subsequent memory recognition paradigm to study amygdala and hippocampus activation in 18 individuals with PTSD and 18 trauma-exposed non-PTSD control participants.Results: Memory enhancement for negative, relative to neutral, pictures was found across all subjects, without significant differences between groups. Relative to the trauma-exposed non-PTSD group, the PTSD group showed exaggerated amygdala activation during the encoding of negative versus neutral pictures. This effect was even more pronounced when the analysis included data from only pictures that were subsequently remembered 1 week later. In the PTSD group, degree of amygdala activation during the encoding of negative versus neutral pictures was positively correlated with hippocampal activation and current PTSD symptom severity. The PTSD group also showed exaggerated hippocampal activation in response to negative pictures that were remembered versus forgotten. Finally, hippocampal activation associated with the successful encoding of negative relative to neutral pictures was significantly greater in the PTSD group.Conclusions: Exaggerated amygdala activation during the encoding of emotionally negative stimuli in PTSD is related to symptom severity and to hippocampal activation.