Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer
Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer
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DOI：
10.1002/path.4021
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发表时间：
2012-12-01
影响因子：
7.3
通讯作者：
Walch, Axel
中科院分区：
文献类型：
--
作者：
Meding, Stephan;Balluff, Benjamin;Walch, Axel
区域淋巴结转移对结肠癌患者的预后有负面影响。导致区域淋巴结转移的分子过程仅被部分理解，并且转移的蛋白质组学标记物仍然很少。因此，一个组织为基础的蛋白质组学的方法进行了鉴定与区域淋巴结转移相关的蛋白质。两种互补的基于组织的蛋白质组学方法已被采用。MALDI成像用于鉴定小蛋白（
Regional lymph node metastasis negatively affects prognosis in colon cancer patients. The molecular processes leading to regional lymph node metastasis are only partially understood and proteomic markers for metastasis are still scarce. Therefore, a tissue-based proteomic approach was undertaken for identifying proteins associated with regional lymph node metastasis. Two complementary tissue-based proteomic methods have been employed. MALDI imaging was used for identifying small proteins (