Proteoglycan as a Key Molecule in Atherosclerosis Progression: Characteristics of the Structure and Regulation of the Synthesis
Proteoglycan as a Key Molecule in Atherosclerosis Progression: Characteristics of the Structure and Regulation of the Synthesis
复制标题
蛋白多糖作为动脉粥样硬化进展的关键分子：结构特征和合成调控
DOI：
10.1002/chin.200831254
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
T. Kaji
中科院分区：
文献类型：
--
作者：
Akiko Urano;C. Yamamoto;Y. Fujiwara;T. Kaji
蛋白多糖是由一个核心蛋白和一个或多个糖胺多聚糖侧链组成的大分子。特别是来源于血管平滑肌细胞的大分子聚集在动脉粥样硬化的血管壁中，参与了血管病变的进展。然而，蛋白多糖的功能取决于核心蛋白的类型和糖胺多糖链的微观结构，这表明调节血管平滑肌细胞蛋白多糖合成的重要性。虽然糖胺多糖链形成的调节尚不清楚，但核心蛋白的合成受生长因子/细胞因子、机械应变、凝血因子等因素的调节。最近，我们发现脂联素，一种具有抗动脉粥样硬化活性的脂肪特异性血浆蛋白，调节血管平滑肌细胞蛋白多糖的合成。
Proteoglycans are macromolecules comprising a core protein and one or more glycosaminoglycan side chains. The macromolecules particularly derived from vascular smooth muscle cells accumulate in atherosclerotic vascular wall and are involved in the progression of vascular lesions. However, the functions of proteoglycans depend on the type of core proteins and microstructure of glycosaminoglycan chains, suggesting importance of the regulation of proteoglycan synthesis in vascular smooth muscle cells. Although the regulation of glycosaminoglycan chain formation is not clear, core protein synthesis is regulated by growth factors/cytokines, mechanical strain, coagulation factors, and other factors. Recently, we found that adiponectin, an adipose-specific plasma protein that exhibits antiatherogenic activities, regulates proteoglycan synthesis in vascular smooth muscle cells.