Morphological and Functional Study of Regenerated Chorda Tympani Nerves in Humans
Morphological and Functional Study of Regenerated Chorda Tympani Nerves in Humans
复制标题
人类再生鼓索神经的形态和功能研究
DOI：
10.1177/000348940010900801
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
H. Saito
中科院分区：
文献类型：
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作者：
Y. Shibamori;Takehito Yamamoto;Takehisa Saito;Y. Manabe;T. Ohtsubo;T. Yamagishi;H. Saito
目前尚不清楚人类的鼓索神经在中耳手术中被切断后是否会再生，尽管功能研究表明味觉在手术后 1 至 2 年内恢复。迄今为止，我们的系列患者在二次手术中已发现12例再生鼓索神经。 12例中有3例在二次手术时取出再生神经作为样本，检测再生有髓轴突。所有再生神经均位于重建鼓膜的粘膜下结缔组织层中。再生神经中，有髓神经纤维存在于小束或结缔组织中，但有髓轴突数量较正常人少（1,752±78；n=3），且分布稀疏。再生有髓轴突总数从 141 个（8.3%）到 979 个（55.9%）不等。根据使用味觉测量的功能研究，在二次手术前，所有 3 例患者均观察到味觉恢复不完全，这表明鼓索神经实际上在中耳中再生并发挥功能。
It is still unclear whether the chorda tympani nerves in humans regenerate after being severed during middle ear surgery, although functional studies have demonstrated recovery of taste 1 to 2 years after surgery. To date, 12 cases of regenerated chorda tympani nerves have been found in our series of patients during secondary surgery. The regenerated nerves of 3 cases of the 12 were removed as samples during secondary surgery to detect regenerated myelinated axons. All regenerated nerves were in the submucosal connective tissue layer of the reconstructed eardrum. In the regenerated nerves, myelinated nerve fibers existed in a small fascicle or in connective tissue, but the number of myelinated axons was low compared with that in normal subjects (1,752 ± 78; n = 3), and the distribution was sparse. The total number of regenerated myelinated axons varied from 141 (8.3%) to 979 (55.9%). From a functional study using electrogustometry, incomplete recovery of electrogustation was observed in all 3 cases before secondary surgery, suggesting that chorda tympani nerves actually regenerate in the middle ear and do function.