Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue
Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue
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DOI：
10.1038/bmt.2016.248
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发表时间：
2017-02-01
影响因子：
4.8
通讯作者：
Shelby, R. A.
中科院分区：
文献类型：
--
作者：
Ghazikhanian, S. E.;Dorfman, C. S.;Shelby, R. A.
认知问题是接受造血干细胞移植（HSCT）的患者的一个重要的、持续的问题。睡眠对许多认知任务都很重要;然而，HSCT患者的睡眠和认知问题之间的关系尚不清楚。本研究探讨了HSCT患者从移植前到移植后的睡眠和认知问题之间的关系。接受HSCT的患者（N= 138）在移植前和移植后12个月内完成了问卷调查。研究人员评估了睡眠和认知问题以及常见的并发症状：抑郁症状，疲劳和疼痛。事后分析研究了特定睡眠问题与认知问题的关系。即使在控制了抑郁症状、疲劳和疼痛之后，睡眠问题与认知问题也存在协变。抑郁症状和疲劳也与认知问题有着独特的联系。事后分析表明，睡眠嗜睡，呼吸急促，打鼾和睡眠不足的看法可能有助于睡眠和认知问题之间的关联。研究结果表明，睡眠问题与HSCT患者的认知问题有关，并可能导致认知问题。然而，睡眠问题很少在诊所就诊时进行筛查或讨论。除了抑郁症状和疲劳外，评估和治疗特定的睡眠问题可能对改善HSCT患者的认知问题有影响。
Cognitive problems are a significant, persistent concern for patients undergoing hematopoietic stem cell transplant (HSCT). Sleep is important for many cognitive tasks; however, the relationship between sleep and cognitive problems for HSCT patients is unknown. This study examined the relationship between sleep and cognitive problems for HSCT patients from pre to post transplant. Patients undergoing HSCT (N= 138) completed questionnaires at pre-transplant and during the 12 months following transplant. Questionnaires assessed sleep and cognitive problems as well as commonly co-occurring symptoms: depressive symptoms, fatigue and pain. Post hoc analyses examined the relationship of specific sleep problems with cognitive problems. Sleep problems covaried with cognitive problems even after controlling for depressive symptoms, fatigue and pain. Depressive symptoms and fatigue were also uniquely related to cognitive problems. Post hoc analyses suggest that sleep somnolence, shortness of breath, snoring and perceptions of inadequate sleep may contribute to the association found between sleep and cognitive problems. Findings suggest that sleep problems are associated with and may contribute to cognitive problems for HSCT patients. However, sleep problems are rarely screened for or discussed during clinic visits. Assessing and treating specific sleep problems in addition to depressive symptoms and fatigue may have implications for improving cognitive problems for HSCT patients.