Effects of nasal obstruction on maturation of the jaw-opening reflex in growing rats
Effects of nasal obstruction on maturation of the jaw-opening reflex in growing rats
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DOI：
10.1016/j.archoralbio.2014.02.013
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发表时间：
2014-05-01
影响因子：
3
通讯作者：
Ono, Takashi
中科院分区：
文献类型：
--
作者：
Funaki, Yukiha;Hiranuma, Maya;Ono, Takashi
目的：观察生长期间鼻塞对颅面形态和功能的影响。然而，这些变化的病因机制尚不清楚。本研究的目的是利用电生理技术研究生长期间鼻塞对张开下巴反射（JOR）成熟的影响。我们关注的是调节口面部肌肉活动和反射的口腔感觉受体。设计：60只6日龄雄性Wistar大鼠随机分为对照组和实验组，每组30只。实验组在8日龄时进行单侧鼻塞。双侧低强度电刺激下肺泡神经诱发JOR。分别在5、7和9周龄时记录双侧二腹肌的肌电反应。结果：各年龄段实验组的JOR潜伏期明显长于对照组，峰峰幅明显小于对照组，持续时间无显著差异。组内比较5、7和9周龄时的潜伏期、峰对峰幅度和持续时间，结果显示对照组和实验组均无显著差异。结论：生长期间单侧鼻塞可能对颅面功能成熟有显著影响。(C) 2014 Elsevier Ltd.版权所有。
Objective: Nasal obstruction during growth changes craniofacial morphology and function. However, the etiological mechanisms of these changes are unknown. The aim of the present study was to investigate the effects of nasal obstruction during growth on the maturation of the jaw-opening reflex (JOR) using an electrophysiological technique. We focused on the oral sensory receptors that regulate the activities and reflexes of the orofacial muscles.Design: Sixty 6-day-old male Wistar rats were randomly divided into control and experimental groups (n = 30 each). The experimental group underwent unilateral nasal obstruction at 8 days of age. The JOR was evoked by bilateral, low-intensity electrical stimulation of the inferior alveolar nerve. The electromyographic responses were recorded bilaterally from the digastric muscles at 5, 7, and 9 weeks of age.Results: The latency of the JOR was significantly longer and the peak-to-peak amplitude was significantly smaller in the experimental group than in the control group at each age, while the duration was not significantly different. Intragroup comparison of the latency, peak-to-peak amplitude, and duration at 5, 7, and 9 weeks of age revealed no significant differences in either the control or experimental groups.Conclusions: Unilateral nasal obstruction during growth may have significant effects on maturation of craniofacial function. (C) 2014 Elsevier Ltd. All rights reserved.